Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects

Background. Sex and gender have a large impact in human health and disease prediction. According to genomic/genetics, men differ from women by a limited number of genes in Y chromosome, while the phenotypes of the 2 sexes differ markedly. Methods. In this study, serum samples from six healthy Bahrai...

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Bibliographic Details
Published in:Genetics Research 2023, Vol.2023, p.8822205-13
Main Authors: Giha, Hayder A., Abdulwahab, Rabab A., Abbas, Jaafar, Shinwari, Zakia, Alaiya, Ayodele
Format: Article
Language:English
Subjects:
Bioinformatics
Biomarkers
Cardiovascular disease
Cholesterol
Chromatography
Chromatography, Liquid
Chromosomes
Connective tissues
Female
Females
Gender
Gene expression
Gene mapping
Genes
Genetics
Genome
Genomes
Globulins
Glucose
Healthy Volunteers
Hemoglobin
High density lipoprotein
Humans
Inflammatory diseases
Lipid metabolism
Lipids
Lipoproteins
Liquid chromatography
Localization
Male
Males
Mass spectrometry
Mass spectroscopy
Men
Peptides
Phenotypes
Physiology
Proteins
Proteomics
Scientific imaging
Sex hormones
Sexes
Software
Tandem Mass Spectrometry
Triglycerides
Variance analysis
Women
Womens health
Y Chromosome
Y chromosomes
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Summary:Background. Sex and gender have a large impact in human health and disease prediction. According to genomic/genetics, men differ from women by a limited number of genes in Y chromosome, while the phenotypes of the 2 sexes differ markedly. Methods. In this study, serum samples from six healthy Bahraini men and women were analyzed by liquid chromatography–mass spectrometry (LC-MS/MS). Bioinformatics databases and tools were used for protein/peptide (PPs) identification and gene localization. The PPs that differed significantly (p 
ISSN:1469-5073
0016-6723
1469-5073
DOI:10.1155/2023/8822205