Registry-derived stage (RD-Stage) for capturing stage at diagnosis for pancreatic carcinoma in Australia

Stage of pancreatic carcinoma at diagnosis is a strong prognostic indicator of morbidity and mortality, yet is poorly notified to population-based cancer registries ("cancer registries"). Registry-derived stage (RD-Stage) provides a method for cancer registries to use available data source...

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Bibliographic Details
Published in:PloS one 2024-01, Vol.19 (1), p.e0294443-e0294443
Main Authors: Evans, Sue M, Ivanova, Kris, Cossio, Danca, Pilgrim, Charles H C, Croagh, Daniel, Zalcberg, John, Giffard, Dalisay, Golobic, Nikkitia, Di Muzio, Bruno, McLean C, Catriona, McLean, Kate, Miller, Gregory C, Nicosia, Susanna, O'Rourke, Nick, Parikh, Sumit, Standish, Richard, Te Marvelde, Luc
Format: Article
Language:English
Subjects:
Australia
Australia - epidemiology
Breast cancer
Cancer
Carcinoma
Care and treatment
Classification
Committees
Completeness
Data sources
Development and progression
Diagnosis
Disease
Endometrial cancer
Endorsements
Epidemiologists
Epidemiology
Gastrointestinal Neoplasms - pathology
Health aspects
Humans
Medical diagnosis
Medical prognosis
Medical research
Medicine and Health Sciences
Meetings
Metastasis
Morbidity
Mortality
Multidisciplinary teams
Neoplasm Staging
Pancreatic cancer
Pancreatic carcinoma
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - pathology
Prostate cancer
Registries
Research ethics
Surgeons
Surveillance
Tumors
United States
Working groups
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Summary:Stage of pancreatic carcinoma at diagnosis is a strong prognostic indicator of morbidity and mortality, yet is poorly notified to population-based cancer registries ("cancer registries"). Registry-derived stage (RD-Stage) provides a method for cancer registries to use available data sources to compile and record stage in a consistent way. This project describes the development and validation of rules to capture RD-Stage (pancreatic carcinoma) and applies the rules to data currently captured in each Australian cancer registry. Rules for deriving RD-stage (pancreatic carcinoma) were developed using the American Joint Commission on Cancer (AJCC) Staging Manual 8th edition and endorsed by an Expert Working Group comprising specialists responsible for delivering care to patients diagnosed with pancreatic carcinoma, cancer registry epidemiologists and medical coders. Completeness of data fields required to calculate RD-Stage (pancreatic carcinoma) and an overall proportion of cases for whom RD stage could be assigned was assessed using data collected by each Australian cancer registry, for period 2018-2019. A validation study compared RD-Stage (pancreatic carcinoma) calculated by the Victorian Cancer Registry with clinical stage captured by the Upper Gastro-intestinal Cancer Registry (UGICR). RD-Stage (pancreatic carcinoma) could not be calculated in 4/8 (50%) of cancer registries; one did not collect the required data elements while three used a staging system not compatible with RD-Stage requirements. Of the four cancer registries able to calculate RD-Stage, baseline completeness ranged from 9% to 76%. Validation of RD-Stage (pancreatic carcinoma) with UGICR data indicated that there was insufficient data available in VCR to stage 174/457 (38%) cases and that stage was unknown in 189/457 (41%) cases in the UGICR. Yet, where it could be derived, there was very good concordance at stage level (I, II, III, IV) between the two datasets. (95.2% concordance], Kendall's coefficient = 0.92). There is a lack of standardisation of data elements and data sources available to cancer registries at a national level, resulting in poor capacity to currently capture RD-Stage (pancreatic carcinoma). RD-Stage provides an excellent tool to cancer registries to capture stage when data elements required to calculate it are available to cancer registries.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0294443