Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3

To investigate phenotypic and genotypic alterations before and after bone metastasis, we conducted genome-wide mRNA profiling and DNA exon sequencing of two cell lines (TMD and BMD) derived from a mouse xenograft model. TMD cells were harvested from the mammary fat pad after transfecting MDA-MB-231...

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Bibliographic Details

Published in:	Scientific reports 2017-06, Vol.7 (1), p.3459-12, Article 3459
Main Authors:	Chen, Andy, Wang, Luqi, Li, Bai-Yan, Sherman, Jesse, Ryu, Jong E, Hamamura, Kazunori, Liu, Yunlong, Nakshatri, Harikrishna, Yokota, Hiroki
Format:	Article
Language:	eng
Subjects:	3',5'-Cyclic-AMP Phosphodiesterases - genetics 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Bone cancer Bone mineral density Breast cancer Calcium-binding protein Cell Line, Tumor Cell migration Cell Movement - genetics Deoxyribonucleic acid DNA DNA fingerprinting DNA sequencing Gene expression Gene Expression Regulation, Neoplastic Genome-Wide Association Study Genomes Glutamic acid receptors (metabotropic) Humans Integrin beta Chains - genetics Integrin beta Chains - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Metastases Metastasis Motility Mutation Nonsense mutation Osteoblasts Paclitaxel Phenotype Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism RNA Interference RNA, Small Interfering - genetics S100 Calcium-Binding Protein A4 - genetics S100 Calcium-Binding Protein A4 - metabolism S100A4 protein Stop codon Xenografts
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