Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study

ObjectivesAlthough COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-...

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Published in:BMJ open 2023-02, Vol.13 (2), p.e063141-e063141
Main Authors: Mohr, Nicholas M, Plumb, Ian D, Harland, Kari K, Pilishvili, Tamara, Fleming-Dutra, Katherine E, Krishnadasan, Anusha, Hoth, Karin F, Saydah, Sharon H, Mankoff, Zachary, Haran, John P, Briggs-Hagen, Melissa, León, Eliezer Santos, Talan, David A, Smithline, Howard A, Hou, Peter C, Lee, Lilly C, Lim, Stephen C, Moran, Gregory J, Steele, Mark T, Beiser, David G, Faine, Brett, Nandi, Utsav, Schrading, Walter A, Chinnock, Brian, Chipman, Anne, Fuentes, Megan, LoVecchio, Frank, Clinansmith, Bradley, Landers, Shannon, Horcher, Alysia, Wallace, Kelli, Uribe, Lisandra, Pathmarajah, Kavitha, Poronsky, Kye E, Hashimoto, Dean M, Bahamon, Monica, Romain, Michelle St, Kean, Efrat, Krebs, Elizabeth, Stubbs, Amy, Roy, Sara, Volturo, Gregory, Higgins, Amanda, Galbraith, James, Crosby, James C, Mulrow, Mary, Gonzalez, Eva, Gierke, Ryan, Farrar, Jennifer L, Xing, Wei, Chung, Yunmi, Yousaf, Anna, Okaro, Jennifer Onukwube, Abedi, Glen R, Nyanseor, Sankan, Watts, Christopher K
Format: Article
Language:English
Subjects:
Cohort analysis
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Vaccines
Data collection
Delivery of Health Care
Drug dosages
EPIDEMIOLOGY
Humans
Infections
Infectious diseases
Medical records
mRNA Vaccines
Prospective Studies
SARS-CoV-2
Sensitivity analysis
Severe acute respiratory syndrome coronavirus 2
Vaccination
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Summary:ObjectivesAlthough COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work.DesignCohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset.SettingHealth systems in 12 US states.ParticipantsHCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset.ExposuresTwo doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine.Main outcome measuresPrevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work.ResultsAmong 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79).ConclusionsReceipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work.
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-063141