N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

Abstract Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m 6 A methylation has attracted increasing research interest in recent years. m...

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Bibliographic Details
Published in:	Molecular cancer 2019-12, Vol.18 (1), p.1-178, Article 178
Main Authors:	Hu, Bin-bin, Wang, Xiao-yan, Gu, Xu-Yu, Zou, Chen, Gao, Zhen-jun, Zhang, Heng, Fan, Yu
Format:	Article
Language:	eng
Subjects:	Antisense RNA Binding proteins Cancer Cancer research Chromatin Decitabine Deoxyribonucleic acid Development and progression DNA DNA methylation DNA sequencing Enzymes Epigenetic inheritance Epigenetics Gastrointestinal system Gastrointestinal tract Gene expression Genetic research Homology Liver cancer Mammals Medical prognosis Metastasis Methylation Methyltransferases MicroRNAs Mortality N6-methyladenosine Phenotypes Protein binding Proteins Pyrimidines Review RNA RNA modification Roles Tumors Writers
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Summary:	Abstract Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m 6 A methylation has attracted increasing research interest in recent years. m 6 A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m 6 A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m 6 A in gastrointestinal tract cancers.
ISSN:	1476-4598 1476-4598