Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design

Inhalation of Calcium Phosphate nanoparticles (CaPs) has recently unmasked the potential of this nanomedicine for a respiratory lung-to-heart drug delivery targeting the myocardial cells. In this work, we investigated the development of a novel highly respirable dry powder embedding crystalline CaPs...

Full description

Saved in:

Bibliographic Details
Published in:	Pharmaceutics 2021-11, Vol.13 (11), p.1825
Main Authors:	Quarta, Eride, Sonvico, Fabio, Bettini, Ruggero, De Luca, Claudio, Dotti, Alessandro, Catalucci, Daniele, Iafisco, Michele, Degli Esposti, Lorenzo, Colombo, Gaia, Trevisi, Giovanna, Rekkas, Dimitrios M., Rossi, Alessandra, Wong, Tin Wui, Buttini, Francesca, Colombo, Paolo
Format:	Article
Language:	eng
Subjects:	calcium phosphate nanoparticles Cardiomyopathy design of experiment Design of experiments Drug dosages Inhalers Manufacturing microparticles embedding nanoparticles Morphology Nanoparticles Particle size Peptides pulmonary delivery Thermogravimetric analysis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Inhalation of Calcium Phosphate nanoparticles (CaPs) has recently unmasked the potential of this nanomedicine for a respiratory lung-to-heart drug delivery targeting the myocardial cells. In this work, we investigated the development of a novel highly respirable dry powder embedding crystalline CaPs. Mannitol was selected as water soluble matrix excipient for constructing respirable dry microparticles by spray drying technique. A Quality by Design approach was applied for understanding the effect of the feed composition and spraying feed rate on typical quality attributes of inhalation powders. The in vitro aerodynamic behaviour of powders was evaluated using a medium resistance device. The inner structure and morphology of generated microparticles were also studied. The 1:4 ratio of CaPs/mannitol led to the generation of hollow microparticles, with the best aerodynamic performance. After microparticle dissolution, the released nanoparticles kept their original size.
ISSN:	1999-4923 1999-4923