Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model

Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer's disease. A common familial Alzheimer's disease transgenic model showed heightened levels of the stress hormone, corticosterone....

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Bibliographic Details

Published in:	Scientific reports 2017-06, Vol.7 (1), p.2764-7, Article 2764
Main Authors:	Stuart, Kimberley E, King, Anna E, Fernandez-Martos, Carmen M, Summers, Mathew J, Vickers, James C
Format:	Article
Language:	eng
Subjects:	Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Cognitive ability Corticosterone Corticosterone - blood Corticosterone - metabolism Disease Models, Animal Environment Glucocorticoids Hormones - blood Hormones - metabolism Humans Hypothalamic-pituitary-adrenal axis Hypothalamus Mice Mice, Transgenic Pathology Pituitary Plaque, Amyloid - genetics Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Presenilins - genetics Presenilins - metabolism Protein Aggregates Protein Aggregation, Pathological - genetics Protein Aggregation, Pathological - metabolism Stress, Psychological - metabolism
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