Paternal Obesity Induced by High-Fat Diet Impairs the Metabolic and Reproductive Health of Progeny in Rats

Due to the increased incidence of obesity, it is of great importance to identify all the possible consequences in those who suffer from it and their descendants. This study aimed to investigate how paternal obesity, resulting from an 18-week high-fat diet (HFD), affects the metabolic and reproductiv...

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Published in:	Metabolites 2023-10, Vol.13 (10), p.1098
Main Authors:	Larqué, Carlos, Lugo-Martínez, Haydée, Mendoza, Xiadany, Nochebuena, Monserrat, Novo, Luis, Vilchis, Ricardo, Sánchez-Bringas, Guadalupe, Ubaldo, Laura, Velasco, Myrian, Escalona, Rene
Format:	Article
Language:	eng
Subjects:	Animals Body mass index Body weight Body weight gain Carbohydrates Dextrose Diabetes therapy Diet Estrus cycle Ethylenediaminetetraacetic acid Females fertility Follicles Glucose High fat diet Infertility intergenerational Leukocytes Males Metabolism Obesity Offspring Oils & fats Plasma Proteins reproduction Reproductive health Rodents Sex differences Sperm Vagina Weaning
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Summary:	Due to the increased incidence of obesity, it is of great importance to identify all the possible consequences in those who suffer from it and their descendants. This study aimed to investigate how paternal obesity, resulting from an 18-week high-fat diet (HFD), affects the metabolic and reproductive health of offspring. In the fathers (F0 generation), the HFD led to significant weight gain, primarily due to increased visceral fat. It also resulted in impaired glucose control and reduced insulin sensitivity. Furthermore, F0 males from the HFD group had reduced sperm concentration and lower sperm viability but were still able to sire litters. F1 offspring were monitored during 18 weeks; F1 offspring from obese fathers displayed increased body weight during the experimental window, especially in males, without significant metabolic disturbances. Additionally, F1 males showed reduced sperm viability, indicating potential reproductive implications. On the other hand, F1 females showed normal estrous cycle patterns but had a reduced number of primordial follicles, suggesting a decrease in their follicular reserve and reproductive potential. This study highlights that metabolic and reproductive issues may be passed down to future generations through the paternal line.
ISSN:	2218-1989 2218-1989