Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma

Gastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumfer...

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Bibliographic Details
Published in:	Frontiers in oncology 2022-08, Vol.12
Main Authors:	Bonometti, Arturo, Aronico, Nicola, Santacroce, Giovanni, Fraticelli, Sara, Lucioni, Marco, Cartia, Claudio Salvatore, Vanoli, Alessandro, Latorre, Mario Andrea, Arcaini, Luca, Paulli, Marco, Di Sabatino, Antonio
Format:	Article
Language:	eng
Subjects:	chemotherapy extramedullary presentation intestinal occlusion Oncology plasma cell myeloma small bowel
Online Access:	Get full text
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Summary:	Gastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumferential thickening of terminal ileum, for which the patient underwent an urgent 20-cm-long ileal resection. Histopathological and immunophenotypic analysis revealed a plasma cell neoplasm of the ileum. Subsequent investigations found a serum monoclonal immunoglobulin A component, an osteolytic lesion of the left jaw, and a clonal bone marrow plasma cell infiltrate carrying 1q21 amplification. Given the final diagnosis of plasma cell myeloma (PCM), the patient underwent a VMD (bortezomib, melphalan, and dexamethasone) chemotherapy regimen, achieving a complete remission after a 12-month treatment. For disease relapse, two further chemotherapy regimens were later attempted. At the last follow-up 4 years after the diagnosis, the patient is still alive. This case draws attention to the extramedullary presentation of plasma cell neoplasms, even if rare, as a prompt diagnosis seems to result in a better prognosis. In addition, it highlights the relevance of a multidisciplinary approach, involving gastroenterologists, hematologists, and pathologists, to the diagnosis and management of these neoplasms.
ISSN:	2234-943X 2234-943X