Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assess...

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Published in:	Nutrients 2018-12, Vol.10 (12), p.2000
Main Authors:	Sánchez-Villegas, Almudena, Álvarez-Pérez, Jacqueline, Toledo, Estefanía, Salas-Salvadó, Jordi, Ortega-Azorín, Carolina, Zomeño, Maria Dolores, Vioque, Jesús, Martínez, Jose Alfredo, Romaguera, Dora, Pérez-López, Jessica, López-Miranda, José, Estruch, Ramón, Bueno-Cavanillas, Aurora, Arós, Fernando, Tur, Josep A, Tinahones, Francisco J, Lecea, Oscar, Martín, Vicente, Ortega-Calvo, M, Vázquez, Clotilde, Pintó, Xavier, Vidal, Josep, Daimiel, Lidia, Delgado-Rodríguez, Miguel, Matía, Pilar, Corella, Dolores, Díaz-López, Andrés, Babio, Nancy, Muñoz, Miguel Ángel, Fitó, Montserrat, García de la Hera, Manoli, Abete, Itziar, García-Rios, Antonio, Ros, Emilio, Ruíz-Canela, Miguel, Martínez-González, Miguel Ángel, Izquierdo, Marisol, Serra-Majem, Lluis
Format:	Article
Language:	eng
Subjects:	Aged Animals Antidepressants Body mass index Confidence intervals Consumption Cross-Sectional Studies depression Depression - epidemiology Depression - prevention & control Depressive Disorder - epidemiology Depressive Disorder - prevention & control Diabetes Diet Diet Surveys docosahexaenoic acid Drug dosages eicosapentaenoic acid Endocrinology Energy Energy Intake Epidemiology Fatty acids Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - therapeutic use Feeding Behavior Female Fish Fishes Food Health care Health sciences Hospitals Humans Hypertension Internal medicine Leisure Logistic Models Male Medical diagnosis Mental depression Metabolism Middle Aged Nutrition research Odds Ratio omega-3 Polyunsaturated fatty acids Prevalence Preventive medicine Public health Questionnaires Regression analysis Regression models Research centers Seafood Signs and symptoms Statistical analysis Studies Surveys and Questionnaires Vegetable oils Womens health
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Summary:	The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
ISSN:	2072-6643 2072-6643