Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented...

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Bibliographic Details

Published in:	Scientific reports 2017-07, Vol.7 (1), p.5986-14, Article 5986
Main Authors:	De Koker, S, Van Hoecke, L, De Beuckelaer, A, Roose, K, Deswarte, K, Willart, M A, Bogaert, P, Naessens, T, De Geest, B G, Saelens, X, Lambrecht, B N, Grooten, J
Format:	Article
Language:	eng
Subjects:	Adjuvants Adjuvants, Immunologic - pharmacology Animals Antigen presentation Antigen Presentation - drug effects Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - metabolism Antigens - metabolism Antigens, Ly - metabolism Cell Movement - drug effects CpG islands Dendritic Cells - drug effects Dendritic Cells - metabolism Immunity, Cellular - drug effects Inflammation Inflammation - pathology Interleukin 12 Interleukin-12 - biosynthesis Lymph Nodes - drug effects Lymph Nodes - metabolism Lymph Nodes - pathology Lymphocytes Lymphocytes T Membrane Proteins - metabolism Mice, Inbred C57BL Monocytes Monocytes - drug effects Monocytes - metabolism Monocytes - pathology Oligodeoxyribonucleotides - pharmacology Oligonucleotides Phenotype Proteins Receptors, CCR2 - metabolism Signal transduction Th1 Cells - immunology TLR9 protein Toll-like receptors Vaccination Vaccines Vaccines - immunology
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