Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier

Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemo...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-09, Vol.10 (10), p.2513
Main Authors: Zhang, Ruiyi, Xue, Mengzhou, Yong, Voon Wee
Format: Article
Language:English
Subjects:
Alzheimer's disease
Angiogenesis
Animal models
Animals
Brain injury
Brain research
Central nervous system
Central Nervous System - pathology
Cerebral Hemorrhage - pathology
Cerebral Hemorrhage - therapy
Hematoma
Hemorrhage
Humans
Hypertension
intracerebral hemorrhage
Microglia
Microglia - cytology
Molecular modelling
Mortality
Multiple sclerosis
Nervous system
Neurogenesis
neuroinflammation
Neurons - cytology
Regeneration
Regeneration - physiology
remyelination
Review
Stroke
Stroke - pathology
Surgery
Tissue engineering
tissue regeneration
Traumatic brain injury
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10102513