Prognostic Value of the Immunohistochemical Expression of Serine and Arginine-Rich Splicing Factor 1 (SRSF1) in Uveal Melanoma: A Clinico-Pathological and Immunohistochemical Study on a Series of 85 Cases

Prognostic Value of the Immunohistochemical Expression of Serine and Arginine-Rich Splicing Factor 1 (SRSF1) in Uveal Melanoma: A Clinico-Pathological and Immunohistochemical Study on a Series of 85 Cases

Uveal melanoma (UM) is the most frequent primary ocular malignancy of adults; it exhibits an almost invariably poor prognosis with onset of liver metastases within 10–15 years after the diagnosis. Serine and arginine-rich splicing factor 1 (SRSF1) is an RNA-binding protein with proto-oncogene functi...

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Bibliographic Details
Published in:Applied sciences 2021-09, Vol.11 (17), p.7874
Main Authors: Broggi, Giuseppe, Falzone, Luca, Fallico, Matteo, Russo, Andrea, Reibaldi, Michele, Longo, Antonio, Avitabile, Teresio, De Pasquale, Rocco, Puzzo, Lidia, Foti, Pietro Valerio, Russo, Daniela, Di Crescenzo, Rosa Maria, Libra, Massimo, Staibano, Stefania, Caltabiano, Rosario
Format: Article
Language:eng
Subjects:
Age
Alternative splicing
Angiogenesis
Antibodies
Growth factors
Immunohistochemistry
Liver
Malignancy
Medical prognosis
Medical research
Melanoma
Metastases
Metastasis
Morphology
MVD
prognostic factor
Proteins
RNA-binding protein
Serine
Splicing
Splicing factors
SRSF1
Survival
Survival analysis
Tumors
Ultrasonic imaging
uveal melanoma
Vascular endothelial growth factor
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Summary:Uveal melanoma (UM) is the most frequent primary ocular malignancy of adults; it exhibits an almost invariably poor prognosis with onset of liver metastases within 10–15 years after the diagnosis. Serine and arginine-rich splicing factor 1 (SRSF1) is an RNA-binding protein with proto-oncogene functions, including stimulation of angiogenesis, cell migration and cell growth; regarding the complex regulation of tumor angiogenesis, it has been suggested that SRSF1 regulates the alternative splicing of vascular endothelial growth factor-α, promoting the formation of its pro-angiogenic isoform. The immunohistochemical expression of SRSF1 on a series of 85 primary UMs, including 39 metastasizing and 46 non-metastasizing cases, was investigated; to clarify the potential pathogenetic role of SRSF1 in this tumor and its effect on angiogenesis, we correlated our immunohistochemical findings with the clinico-pathological features, the prognostic data and blood vascular microvessel density (MVD) findings of the cases from our series. Cases with higher immunohistochemical expression of SRSF1 also had higher MVD, higher metastatic potential and shorter metastasis-free survival; conversely, cases with lower SRSF1 immunoexpression showed lower MVD, lower metastatic risk and longer metastasis-free survival times. Our results suggested that SRSF1 has a negative prognostic role and a pro-angiogenic function in UM.
ISSN:2076-3417
2076-3417