Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfac...

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Published in:	eLife 2018-06, Vol.7
Main Authors:	Kaucka, Marketa, Petersen, Julian, Tesarova, Marketa, Szarowska, Bara, Kastriti, Maria Eleni, Xie, Meng, Kicheva, Anna, Annusver, Karl, Kasper, Maria, Symmons, Orsolya, Pan, Leslie, Spitz, Francois, Kaiser, Jozef, Hovorakova, Maria, Zikmund, Tomas, Sunadome, Kazunori, Matise, Michael P, Wang, Hui, Marklund, Ulrika, Abdo, Hind, Ernfors, Patrik, Maire, Pascal, Wurmser, Maud, Chagin, Andrei S, Fried, Kaj, Adameyko, Igor
Format:	Article
Language:	eng
Subjects:	Animals Bones Brain - drug effects Brain - growth & development Brain - metabolism Cartilage cartilage induction Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism cleft palate Collagen Type II - genetics Collagen Type II - metabolism Developmental Biology Embryo, Mammalian embryonic development Embryos Face - anatomy & histology Face - embryology Facial Bones - cytology Facial Bones - drug effects Facial Bones - growth & development Facial Bones - metabolism facial shaping Gene Expression Regulation, Developmental Geometry Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Integrases - genetics Integrases - metabolism Jaw mammalian face Maxilla Maxillofacial Development - genetics Medicin och hälsovetenskap Mice Mice, Transgenic Morphogenesis Morphogenesis - drug effects Morphogenesis - genetics Mutagens - administration & dosage Nasal Cartilages - cytology Nasal Cartilages - drug effects Nasal Cartilages - growth & development Nasal Cartilages - metabolism Nervous system Neurosciences Olfactory epithelium Olfactory Mucosa - cytology Olfactory Mucosa - drug effects Olfactory Mucosa - growth & development Olfactory Mucosa - metabolism Pattern recognition Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Regulatory sequences Septum Signal Transduction sonic hedgehog Tamoxifen - administration & dosage Transcription Factors - genetics Transcription Factors - metabolism Zebrafish Proteins
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