Intra-tidal PaO2 oscillations associated with mechanical ventilation: a pilot study to identify discrete morphologies in a porcine model
Background Within-breath oscillations in arterial oxygen tension (PaO 2 ) can be detected using fast responding intra-arterial oxygen sensors in animal models. These PaO 2 signals, which rise in inspiration and fall in expiration, may represent cyclical recruitment/derecruitment and, therefore, a po...
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| Published in: | Intensive care medicine experimental 2023-09, Vol.11 (1), p.60-60, Article 60 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Background
Within-breath oscillations in arterial oxygen tension (PaO
2
) can be detected using fast responding intra-arterial oxygen sensors in animal models. These PaO
2
signals, which rise in inspiration and fall in expiration, may represent cyclical recruitment/derecruitment and, therefore, a potential clinical monitor to allow titration of ventilator settings in lung injury. However, in hypovolaemia models, these oscillations have the potential to become inverted, such that they decline, rather than rise, in inspiration. This inversion suggests multiple aetiologies may underlie these oscillations. A correct interpretation of the various PaO
2
oscillation morphologies is essential to translate this signal into a monitoring tool for clinical practice. We present a pilot study to demonstrate the feasibility of a new analysis method to identify these morphologies.
Methods
Seven domestic pigs (average weight 31.1 kg) were studied under general anaesthesia with muscle relaxation and mechanical ventilation. Three underwent saline-lavage lung injury and four were uninjured. Variations in PEEP, tidal volume and presence/absence of lung injury were used to induce different morphologies of PaO
2
oscillation. Functional principal component analysis and
k
-means clustering were employed to separate PaO
2
oscillations into distinct morphologies, and the cardiorespiratory physiology associated with these PaO
2
morphologies was compared.
Results
PaO
2
oscillations from 73 ventilatory conditions were included. Five functional principal components were sufficient to explain ≥ 95% of the variance of the recorded PaO
2
signals. From these, five unique morphologies of PaO
2
oscillation were identified, ranging from those which increased in inspiration and decreased in expiration, through to those which decreased in inspiration and increased in expiration. This progression was associated with the estimates of the first functional principal component (
P
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| ISSN: | 2197-425X 2197-425X |