Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study

Decompression sickness (DCS) is a systemic syndrome that can occur after an environmental pressure reduction. Previously, we showed that the plasmatic tetrameric form of transthyretin (TTR) nearly disappeared in rats suffering DCS but not in asymptomatic ones. In this pilot study, we assessed whethe...

Full description

Saved in:
Bibliographic Details
Published in:Physiological reports 2024-07, Vol.12 (14), p.e16160-n/a
Main Authors: Orsat, J., Guernec, A., Le Maréchal, C., Pichereau, V., Guerrero, F.
Format: Article
Language:English
Subjects:
Alleles
Animals
Asymptomatic
Decompression
decompression sickness
Decompression Sickness - genetics
Decompression Sickness - metabolism
Disease Resistance - genetics
Female
Females
Gene expression
Gene polymorphism
Life Sciences
Liver
Liver - metabolism
Male
Males
Mutation
Original
Oxidative stress
Physiology
Pilot Projects
Polymorphism, Single Nucleotide
Prealbumin - genetics
Prealbumin - metabolism
Proteins
rat
Rats
Rats, Wistar
Regular Manuscript
RNA, Messenger - genetics
RNA, Messenger - metabolism
Single-nucleotide polymorphism
Thymine
Transthyretin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c5080-5b0c86addab60380016e328ee051027ac604bc0618779546d38be3e09cf1f2c53
container_end_page n/a
container_issue 14
container_start_page e16160
container_title Physiological reports
container_volume 12
creator Orsat, J.
Guernec, A.
Le Maréchal, C.
Pichereau, V.
Guerrero, F.
description Decompression sickness (DCS) is a systemic syndrome that can occur after an environmental pressure reduction. Previously, we showed that the plasmatic tetrameric form of transthyretin (TTR) nearly disappeared in rats suffering DCS but not in asymptomatic ones. In this pilot study, we assessed whether the resistance to DCS could be associated with polymorphism of the gene of TTR. For this study, Sanger sequencing was performed on purified PCR products from the liver of 14‐week‐old male and female standard and DCS‐resistant rats (n = 5 per group). Hepatic TTR mRNA expression was assessed by RT‐qPCR in 18–19 week‐old male and female standard and resistant rats (n = 6 per group). There is a synonymous single nucleotide polymorphism (SNP) on the third base of codon 46 (c.138 C > T). The thymine allele was present in 90% and 100% of males and females standard, respectively. However, this allele is present in only 30% of DCS‐resistant males and females (p = 0.0002301). In the liver, there is a significant effect of the resistance to DCS (p = 0.043) and sex (p = 0.047) on TTR expression. Levels of TTR mRNA were lower in DCS‐resistant animals. To conclude, DCS resistance might be associated with a SNP and a lower expression of TTR.
doi_str_mv 10.14814/phy2.16160
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_77e57f7640d2498ca155f7b97ff4b71b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_77e57f7640d2498ca155f7b97ff4b71b</doaj_id><sourcerecordid>3083680378</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5080-5b0c86addab60380016e328ee051027ac604bc0618779546d38be3e09cf1f2c53</originalsourceid><addsrcrecordid>eNp9ksFu1DAQQCMEolXpiTuyxAVEt9hxYjtc0KoCttJKcAAJTpbjTHZdEju1nZb8AN-Nd9NWbQ-cPJp5fvaMJsteEnxKCkGK98N2yk8JIww_yQ5zXJKFIPzn03vxQXYcwgXGmGBKK1w8zw7SQauCksPs7zIEp42KxllUQ7wGsMiriBrQrh88hLCrBKN_2xSjlDAhKqvhBEWvbIjbyUM0O8RuOkB21B24aBpAg-um3vlha0J_gpRtEPy5NX5ASzSYzkUU4thML7JnreoCHN-cR9mPz5--n60W669fzs-W64UuscCLssZaMNU0qmaYitQSA5oLgNQrzrnSDBe1xowIzquyYA0VNVDAlW5Jm-uSHmXns7dx6kIO3vTKT9IpI_cJ5zdS-WhSC5JzKHnLWYGbvKiEVqQsW15XvG2LmpM6uT7OrmGse2g02DSQ7oH0YcWardy4K0lIzvKqEsnwdjZsH91bLddyl8MFY7xk7Iok9s3Na95djhCi7E3Q0HXKghuDpFhQJjDlO-3rR-iFG71Nc91RZc4rynii3s2U9i4ED-3dDwiW-92Su92S-91K9Kv7zd6xt5uUgHwGrk0H0_9c8tvqVz5b_wHX-Nt1</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3085279367</pqid></control><display><type>article</type><title>Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study</title><source>Wiley-Blackwell Titles (Open access)</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Orsat, J. ; Guernec, A. ; Le Maréchal, C. ; Pichereau, V. ; Guerrero, F.</creator><creatorcontrib>Orsat, J. ; Guernec, A. ; Le Maréchal, C. ; Pichereau, V. ; Guerrero, F.</creatorcontrib><description>Decompression sickness (DCS) is a systemic syndrome that can occur after an environmental pressure reduction. Previously, we showed that the plasmatic tetrameric form of transthyretin (TTR) nearly disappeared in rats suffering DCS but not in asymptomatic ones. In this pilot study, we assessed whether the resistance to DCS could be associated with polymorphism of the gene of TTR. For this study, Sanger sequencing was performed on purified PCR products from the liver of 14‐week‐old male and female standard and DCS‐resistant rats (n = 5 per group). Hepatic TTR mRNA expression was assessed by RT‐qPCR in 18–19 week‐old male and female standard and resistant rats (n = 6 per group). There is a synonymous single nucleotide polymorphism (SNP) on the third base of codon 46 (c.138 C &gt; T). The thymine allele was present in 90% and 100% of males and females standard, respectively. However, this allele is present in only 30% of DCS‐resistant males and females (p = 0.0002301). In the liver, there is a significant effect of the resistance to DCS (p = 0.043) and sex (p = 0.047) on TTR expression. Levels of TTR mRNA were lower in DCS‐resistant animals. To conclude, DCS resistance might be associated with a SNP and a lower expression of TTR.</description><identifier>ISSN: 2051-817X</identifier><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.16160</identifier><identifier>PMID: 39039431</identifier><language>eng</language><publisher>United States: John Wiley &amp; Sons, Inc</publisher><subject>Alleles ; Animals ; Asymptomatic ; Decompression ; decompression sickness ; Decompression Sickness - genetics ; Decompression Sickness - metabolism ; Disease Resistance - genetics ; Female ; Females ; Gene expression ; Gene polymorphism ; Life Sciences ; Liver ; Liver - metabolism ; Male ; Males ; Mutation ; Original ; Oxidative stress ; Physiology ; Pilot Projects ; Polymorphism, Single Nucleotide ; Prealbumin - genetics ; Prealbumin - metabolism ; Proteins ; rat ; Rats ; Rats, Wistar ; Regular Manuscript ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Single-nucleotide polymorphism ; Thymine ; Transthyretin</subject><ispartof>Physiological reports, 2024-07, Vol.12 (14), p.e16160-n/a</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5080-5b0c86addab60380016e328ee051027ac604bc0618779546d38be3e09cf1f2c53</cites><orcidid>0000-0003-1078-9407 ; 0000-0002-5575-5131 ; 0000-0002-0283-3503 ; 0000-0001-9025-3797</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3085279367/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3085279367?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,11576,25767,27938,27939,37026,37027,44604,46066,46490,53806,53808,75462</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39039431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-brest.fr/hal-04667566$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Orsat, J.</creatorcontrib><creatorcontrib>Guernec, A.</creatorcontrib><creatorcontrib>Le Maréchal, C.</creatorcontrib><creatorcontrib>Pichereau, V.</creatorcontrib><creatorcontrib>Guerrero, F.</creatorcontrib><title>Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>Decompression sickness (DCS) is a systemic syndrome that can occur after an environmental pressure reduction. Previously, we showed that the plasmatic tetrameric form of transthyretin (TTR) nearly disappeared in rats suffering DCS but not in asymptomatic ones. In this pilot study, we assessed whether the resistance to DCS could be associated with polymorphism of the gene of TTR. For this study, Sanger sequencing was performed on purified PCR products from the liver of 14‐week‐old male and female standard and DCS‐resistant rats (n = 5 per group). Hepatic TTR mRNA expression was assessed by RT‐qPCR in 18–19 week‐old male and female standard and resistant rats (n = 6 per group). There is a synonymous single nucleotide polymorphism (SNP) on the third base of codon 46 (c.138 C &gt; T). The thymine allele was present in 90% and 100% of males and females standard, respectively. However, this allele is present in only 30% of DCS‐resistant males and females (p = 0.0002301). In the liver, there is a significant effect of the resistance to DCS (p = 0.043) and sex (p = 0.047) on TTR expression. Levels of TTR mRNA were lower in DCS‐resistant animals. To conclude, DCS resistance might be associated with a SNP and a lower expression of TTR.</description><subject>Alleles</subject><subject>Animals</subject><subject>Asymptomatic</subject><subject>Decompression</subject><subject>decompression sickness</subject><subject>Decompression Sickness - genetics</subject><subject>Decompression Sickness - metabolism</subject><subject>Disease Resistance - genetics</subject><subject>Female</subject><subject>Females</subject><subject>Gene expression</subject><subject>Gene polymorphism</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Males</subject><subject>Mutation</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Physiology</subject><subject>Pilot Projects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prealbumin - genetics</subject><subject>Prealbumin - metabolism</subject><subject>Proteins</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regular Manuscript</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Single-nucleotide polymorphism</subject><subject>Thymine</subject><subject>Transthyretin</subject><issn>2051-817X</issn><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9ksFu1DAQQCMEolXpiTuyxAVEt9hxYjtc0KoCttJKcAAJTpbjTHZdEju1nZb8AN-Nd9NWbQ-cPJp5fvaMJsteEnxKCkGK98N2yk8JIww_yQ5zXJKFIPzn03vxQXYcwgXGmGBKK1w8zw7SQauCksPs7zIEp42KxllUQ7wGsMiriBrQrh88hLCrBKN_2xSjlDAhKqvhBEWvbIjbyUM0O8RuOkB21B24aBpAg-um3vlha0J_gpRtEPy5NX5ASzSYzkUU4thML7JnreoCHN-cR9mPz5--n60W669fzs-W64UuscCLssZaMNU0qmaYitQSA5oLgNQrzrnSDBe1xowIzquyYA0VNVDAlW5Jm-uSHmXns7dx6kIO3vTKT9IpI_cJ5zdS-WhSC5JzKHnLWYGbvKiEVqQsW15XvG2LmpM6uT7OrmGse2g02DSQ7oH0YcWardy4K0lIzvKqEsnwdjZsH91bLddyl8MFY7xk7Iok9s3Na95djhCi7E3Q0HXKghuDpFhQJjDlO-3rR-iFG71Nc91RZc4rynii3s2U9i4ED-3dDwiW-92Su92S-91K9Kv7zd6xt5uUgHwGrk0H0_9c8tvqVz5b_wHX-Nt1</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Orsat, J.</creator><creator>Guernec, A.</creator><creator>Le Maréchal, C.</creator><creator>Pichereau, V.</creator><creator>Guerrero, F.</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1078-9407</orcidid><orcidid>https://orcid.org/0000-0002-5575-5131</orcidid><orcidid>https://orcid.org/0000-0002-0283-3503</orcidid><orcidid>https://orcid.org/0000-0001-9025-3797</orcidid></search><sort><creationdate>202407</creationdate><title>Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study</title><author>Orsat, J. ; Guernec, A. ; Le Maréchal, C. ; Pichereau, V. ; Guerrero, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5080-5b0c86addab60380016e328ee051027ac604bc0618779546d38be3e09cf1f2c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Asymptomatic</topic><topic>Decompression</topic><topic>decompression sickness</topic><topic>Decompression Sickness - genetics</topic><topic>Decompression Sickness - metabolism</topic><topic>Disease Resistance - genetics</topic><topic>Female</topic><topic>Females</topic><topic>Gene expression</topic><topic>Gene polymorphism</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Males</topic><topic>Mutation</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Physiology</topic><topic>Pilot Projects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prealbumin - genetics</topic><topic>Prealbumin - metabolism</topic><topic>Proteins</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regular Manuscript</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Single-nucleotide polymorphism</topic><topic>Thymine</topic><topic>Transthyretin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orsat, J.</creatorcontrib><creatorcontrib>Guernec, A.</creatorcontrib><creatorcontrib>Le Maréchal, C.</creatorcontrib><creatorcontrib>Pichereau, V.</creatorcontrib><creatorcontrib>Guerrero, F.</creatorcontrib><collection>Wiley-Blackwell Titles (Open access)</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orsat, J.</au><au>Guernec, A.</au><au>Le Maréchal, C.</au><au>Pichereau, V.</au><au>Guerrero, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2024-07</date><risdate>2024</risdate><volume>12</volume><issue>14</issue><spage>e16160</spage><epage>n/a</epage><pages>e16160-n/a</pages><issn>2051-817X</issn><eissn>2051-817X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Decompression sickness (DCS) is a systemic syndrome that can occur after an environmental pressure reduction. Previously, we showed that the plasmatic tetrameric form of transthyretin (TTR) nearly disappeared in rats suffering DCS but not in asymptomatic ones. In this pilot study, we assessed whether the resistance to DCS could be associated with polymorphism of the gene of TTR. For this study, Sanger sequencing was performed on purified PCR products from the liver of 14‐week‐old male and female standard and DCS‐resistant rats (n = 5 per group). Hepatic TTR mRNA expression was assessed by RT‐qPCR in 18–19 week‐old male and female standard and resistant rats (n = 6 per group). There is a synonymous single nucleotide polymorphism (SNP) on the third base of codon 46 (c.138 C &gt; T). The thymine allele was present in 90% and 100% of males and females standard, respectively. However, this allele is present in only 30% of DCS‐resistant males and females (p = 0.0002301). In the liver, there is a significant effect of the resistance to DCS (p = 0.043) and sex (p = 0.047) on TTR expression. Levels of TTR mRNA were lower in DCS‐resistant animals. To conclude, DCS resistance might be associated with a SNP and a lower expression of TTR.</abstract><cop>United States</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>39039431</pmid><doi>10.14814/phy2.16160</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1078-9407</orcidid><orcidid>https://orcid.org/0000-0002-5575-5131</orcidid><orcidid>https://orcid.org/0000-0002-0283-3503</orcidid><orcidid>https://orcid.org/0000-0001-9025-3797</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2051-817X
ispartof Physiological reports, 2024-07, Vol.12 (14), p.e16160-n/a
issn 2051-817X
2051-817X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_77e57f7640d2498ca155f7b97ff4b71b
source Wiley-Blackwell Titles (Open access); Publicly Available Content Database; PubMed Central
subjects Alleles
Animals
Asymptomatic
Decompression
decompression sickness
Decompression Sickness - genetics
Decompression Sickness - metabolism
Disease Resistance - genetics
Female
Females
Gene expression
Gene polymorphism
Life Sciences
Liver
Liver - metabolism
Male
Males
Mutation
Original
Oxidative stress
Physiology
Pilot Projects
Polymorphism, Single Nucleotide
Prealbumin - genetics
Prealbumin - metabolism
Proteins
rat
Rats
Rats, Wistar
Regular Manuscript
RNA, Messenger - genetics
RNA, Messenger - metabolism
Single-nucleotide polymorphism
Thymine
Transthyretin
title Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-02T09%3A21%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20rat%20decompression%20sickness%20resistance,%20transthyretin%20single%20nucleotide%20polymorphism,%20and%20expression:%20A%20pilot%20study&rft.jtitle=Physiological%20reports&rft.au=Orsat,%20J.&rft.date=2024-07&rft.volume=12&rft.issue=14&rft.spage=e16160&rft.epage=n/a&rft.pages=e16160-n/a&rft.issn=2051-817X&rft.eissn=2051-817X&rft_id=info:doi/10.14814/phy2.16160&rft_dat=%3Cproquest_doaj_%3E3083680378%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5080-5b0c86addab60380016e328ee051027ac604bc0618779546d38be3e09cf1f2c53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3085279367&rft_id=info:pmid/39039431&rfr_iscdi=true