Dietary Salt Restriction in Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials

A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. We p...

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Bibliographic Details
Published in:	Nutrients 2018-06, Vol.10 (6), p.732
Main Authors:	Garofalo, Carlo, Borrelli, Silvio, Provenzano, Michele, De Stefano, Toni, Vita, Carlo, Chiodini, Paolo, Minutolo, Roberto, Nicola, Luca De, Conte, Giuseppe
Format:	Article
Language:	eng
Subjects:	Blood pressure chronic kidney disease Clinical trials Dialysis Diet dietary salt restriction Excretion Kidney diseases Kidneys Medical research Meta-analysis Patients Proteinuria Randomization Review Salts Sodium Subgroups Systematic review
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Summary:	A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. We performed a meta-analysis of randomized controlled trials (RCTs) evaluating the effects of low versus high salt intake in adult patients with non-dialysis CKD on change in BP, proteinuria and albuminuria. Eleven RCTs were selected and included information about 738 CKD patients (Stage 1⁻4); urinary sodium excretion was 104 mEq/day (95%CI, 76⁻131) and 179 mEq/day (95%CI, 165⁻193) in low- and high-sodium intake subgroups, respectively, with a mean difference of −80 mEq/day (95%CI from −107 to −53;
ISSN:	2072-6643 2072-6643