The Prevalence of Anti-Hexokinase-1 and Anti-Kelch-Like 12 Peptide Antibodies in Patients With Primary Biliary Cholangitis Is Similar in Europe and North America: A Large International, Multi-Center Study

Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is present worldwide. Autoantibodies, in particular anti-mitochondrial antibodies (AMA) detected by indirect immunofluorescence assays or newer solid phase immunoassays can detect most, but not all individuals with PBC....

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Bibliographic Details
Published in:	Frontiers in immunology 2019-04, Vol.10, p.662-662
Main Authors:	Norman, Gary L, Reig, Anna, Viñas, Odette, Mahler, Michael, Wunsch, Ewa, Milkiewicz, Piotr, Swain, Mark G, Mason, Andrew, Stinton, Laura M, Aparicio, Maria Belen, Aldegunde, Maria Jose, Fritzler, Marvin J, Parés, Albert
Format:	Article
Language:	eng
Subjects:	AMA-negative anti-mitochondrial antibodies autoantibodies Care and treatment Cholangitis hexokinase-1 Hexokinases Immunology kelch-like 12 Peptides primary biliary cholangitis Risk factors
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Summary:	Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is present worldwide. Autoantibodies, in particular anti-mitochondrial antibodies (AMA) detected by indirect immunofluorescence assays or newer solid phase immunoassays can detect most, but not all individuals with PBC. Detection of antibodies to the anti-nuclear antigens sp100 and gp210 can identify additional PBC patients, but some seronegative patients remain, often resulting in delayed diagnosis and treatment. Antibodies to kelch-like 12 (KLHL12) and hexokinase 1 (HK-1) were recently identified as new biomarkers for PBC and notably identify patients who are negative for conventional autoantibodies. To become globally adopted, it is important to validate these new biomarkers in different geographic areas. In the present study we evaluated the prevalence of anti-KLHL12 (measured by a KLHL12-derived peptide referred to as KL-p) and anti-HK-1 antibodies by ELISA at five sites within Europe and North America and demonstrated the presence of these antibodies in patients with PBC in all geographies.
ISSN:	1664-3224 1664-3224