β-Carotene from the Alga Dunaliella bardawil Decreases Gene Expression of Adipose Tissue Macrophage Recruitment Markers and Plasma Lipid Concentrations in Mice Fed a High-Fat Diet

β-Carotene from the Alga Dunaliella bardawil Decreases Gene Expression of Adipose Tissue Macrophage Recruitment Markers and Plasma Lipid Concentrations in Mice Fed a High-Fat Diet

Vitamin A and provitamin A carotenoids are involved in the regulation of adipose tissue metabolism and inflammation. We examined the effect of dietary supplementation using all-trans and 9-cis β-carotene-rich Dunaliella bardawil alga as the sole source of vitamin A on obesity-associated comorbiditie...

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Bibliographic Details
Published in:Marine drugs 2022-06, Vol.20 (7), p.433
Main Authors: Melnikov, Nir, Kamari, Yehuda, Kandel-Kfir, Michal, Barshack, Iris, Ben-Amotz, Ami, Harats, Dror, Shaish, Aviv, Harari, Ayelet
Format: Article
Language:eng
Subjects:
Adipocytes
Adipose tissue
Algae
Biomarkers
Body fat
Carotene
Carotenoids
Cholesterol
Comorbidity
Diabetes
Diet
Dietary supplements
Dunaliella
Dunaliella bardawil
Gene expression
Glucose
High fat diet
Hypotheses
Lipids
Liver
Macrophages
Metabolism
mice
Monocyte chemoattractant protein 1
Nutrient deficiency
Obesity
Plasma
Recruitment
Recruitment (fisheries)
Retinene
Triglycerides
Vitamin A
Vitamins
β-Carotene
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Summary:Vitamin A and provitamin A carotenoids are involved in the regulation of adipose tissue metabolism and inflammation. We examined the effect of dietary supplementation using all-trans and 9-cis β-carotene-rich Dunaliella bardawil alga as the sole source of vitamin A on obesity-associated comorbidities and adipose tissue dysfunction in a diet-induced obesity mouse model. Three-week-old male mice (C57BL/6) were randomly allocated into two groups and fed a high-fat, vitamin A-deficient diet supplemented with either vitamin A (HFD) or β-carotene (BC) (HFD-BC). Vitamin A levels in the liver, WATs, and BAT of the HFD-BC group were 1.5–2.4-fold higher than of the HFD group. BC concentrations were 5–6-fold greater in BAT compared to WAT in the HFD-BC group. The eWAT mRNA levels of the Mcp-1 and Cd68 were 1.6- and 2.1-fold lower, respectively, and the plasma cholesterol and triglyceride concentrations were 30% and 28% lower in the HFD-BC group compared with the HFD group. Dietary BC can be the exclusive vitamin A source in mice fed a high-fat diet, as shown by the vitamin A concentration in the plasma and tissues. Feeding BC rather than vitamin A reduces adipose tissue macrophage recruitment markers and plasma lipid concentrations.
ISSN:1660-3397
1660-3397