Prevalence of and risk factors for metabolic associated fatty liver disease in an urban population in China: a cross-sectional comparative study

Metabolic associated fatty liver disease (MAFLD) is a new definition for liver disease associated with known metabolic dysfunction. Based on new diagnostic criteria, we aimed to investigate its prevalence and risk factors in Chinese population. We conducted this study in a health examination populat...

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Published in:	BMC gastroenterology 2021-05, Vol.21 (1), p.212-212, Article 212
Main Authors:	Chen, Yu-Ling, Li, Hao, Li, Shu, Xu, Zhou, Tian, Shen, Wu, Juan, Liang, Xin-Yu, Li, Xin, Liu, Zi-Li, Xiao, Jun, Wei, Jia-Ying, Ma, Chen-Yu, Wu, Kai-Nan, Ran, Liang, Kong, Ling-Quan
Format:	Article
Language:	eng
Subjects:	Abdomen Age Alanine Alanine transaminase Blood pressure Body mass index Body weight Cholesterol Dyslipidemia Fasting Fatty liver Females Gastroenterology Glucose Hospitals Hyperuricemia Laboratories Liver diseases Males Menopause Metabolic associated fatty liver disease Metabolic disorders Metabolic syndrome Nonalcoholic fatty liver disease Obesity Overweight Post-menopause Quality control Risk factors Triglycerides Ultrasonic imaging Ultrasonography Underweight Uric acid Womens health
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Summary:	Metabolic associated fatty liver disease (MAFLD) is a new definition for liver disease associated with known metabolic dysfunction. Based on new diagnostic criteria, we aimed to investigate its prevalence and risk factors in Chinese population. We conducted this study in a health examination population who underwent abdominal ultrasonography in China. The diagnosis of MAFLD was based on the new diagnostic criteria. The characteristics of the MAFLD population, as well as the associations between MAFLD and metabolic abnormalities, were explored. Mann-Whitney U test and chi-square test were performed to compare different variables. Binary logistic regression was used to determine the risk factors for MAFLD. Among 139,170 subjects, the prevalence of MAFLD was 26.1% (males: 35.4%; females: 14.1%). The prevalence based on female menopausal status, that is, premenopausal, perimenopausal, and postmenopausal, was 6.1%, 16.8%, and 30.2%, respectively. In different BMI groups (underweight, normal, overweight and obese), the prevalence was 0.1%, 4.0%, 27.4% and 59.8%, respectively. The proportions of abnormal metabolic features in the MAFLD group were significantly higher than those in the non-MAFLD group, as was the proportion of elevated alanine aminotransferase (ALT) (42.5% vs. 11%, P
ISSN:	1471-230X 1471-230X