New Biocides Based on N4-Alkylcytidines: Effects on Microorganisms and Application for the Protection of Cultural Heritage Objects of Painting

The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series...

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Published in:International journal of molecular sciences 2024-03, Vol.25 (5), p.3053
Main Authors: Alexandrova, Liudmila A., Oskolsky, Ivan A., Makarov, Dmitry A., Jasko, Maxim V., Karpenko, Inna L., Efremenkova, Olga V., Vasilyeva, Byazilya F., Avdanina, Darya A., Ermolyuk, Anna A., Benko, Elizaveta E., Kalinin, Stanislav G., Kolganova, Tat’yana V., Berzina, Maria Ya, Konstantinova, Irina D., Chizhov, Alexander O., Kochetkov, Sergey N., Zhgun, Alexander A.
Format: Article
Language:English
Subjects:
antibacterial activity
Antibiotics
antifungal activity
Antimicrobial agents
Bacterial infections
biocides
biodeterioration
Cultural heritage
Cytotoxicity
Drug resistance
Gram-positive bacteria
Microorganisms
N4-alkylcytidines
nucleosides
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Summary:The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series of N4-alkylcytidines, including 5- and 6-methylcytidine derivatives, with extended alkyl substituents, were obtained in order to develop a new generation of antibacterial and antifungal biocides based on nucleoside derivatives. It has been shown that N4-alkyl 5- or 6-methylcytidines effectively inhibit the growth of molds, isolated from the paintings in the halls of the Ancient Russian Paintings of the State Tretyakov Gallery, Russia, Moscow. The novel compounds showed activity similar to antiseptics commonly used to protect works of art, such as benzalkonium chloride, to which a number of microorganisms have acquired resistance. It was also shown that the activity of N4-alkylcytidines is comparable to that of some antibiotics used in medicine to fight Gram-positive bacteria, including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis. N4-dodecyl-5- and 6-methylcytidines turned out to be the best. This compound seems promising for expanding the palette of antiseptics used in painting, since quite often the destruction of painting materials is caused by joint fungi and bacteria infection.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25053053