Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple

Ultra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-perfo...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-05, Vol.23 (5), p.1060
Main Authors: Guo, Jing, Li, Minmin, Liu, Yongguo, Wang, Fengzhong, Kong, Zhiqiang, Sun, Yufeng, Lu, Jia, Jin, Nuo, Huang, Yatao, Liu, Jiameng, Francis, Frédéric, Fan, Bei
Format: Article
Language:English
Subjects:
Agricultural practices
Agrochemicals
chiral cyflumetofen
Chromatography
Convergence
dietary risk assessment
distribution
Enantiomers
enantioselective degradation
Food Analysis - methods
Food science
Fruit - chemistry
Health risks
Humans
Life sciences
Malus - chemistry
Mass spectrometry
Mass spectroscopy
Organic solvents
Pesticides
Propionates - analysis
Risk Assessment
Sciences des denrées alimentaires
Sciences du vivant
Sensitivity analysis
Stereoisomers
ultra-performance convergence chromatography
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Summary:Ultra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-performance convergence chromatography coupled with tandem mass spectrometry, which shows that stereoisomer recoveries determined for various apple parts ranged from 78.3% to 119.9%, with the relative standard deviations being lower than 14.0%. The half-lives of (−)-cyflumetofen and (+)-cyflumetofen obtained under 5-fold applied dosage equal to 22.13 and 22.23 days, respectively. For 1.5-fold applied dosage, the respective values were determined as 22.42 and 23.64 days, i.e., the degradation of (−)-cyflumetofen was insignificantly favored over that of its enantiomer. Importantly, cyflumetofen was unevenly distributed in apples, with its relative contents in apple peel, peduncle, and pomace equal to 50%, 22%, and 16%, respectively. The proposed method can be used to efficiently separate and quantify chiral pesticide with advantages of a shorter analysis time, greater sensitivity, and better environmental compatibility. Additionally, the consumption of apples with residue of cyflumetofen did not pose a health risk to the population if the cyflumetofen applied under satisfactory agricultural practices after the long-term dietary risk assessment.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23051060