Cardiovascular reflex contributions to sympathetic inhibition during low intensity dynamic leg exercise in healthy middle‐age

Aging augments resting muscle sympathetic nerve activity (MSNA) and sympatho‐inhibition during mild dynamic 1‐leg exercise. To elucidate which reflexes elicit exercise‐induced inhibition, we recruited 19 (9 men) healthy volunteers (mean age 56 ± 9 SD years), assessed their peak oxygen uptake (VO2pea...

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Bibliographic Details
Published in:	Physiological reports 2023-09, Vol.11 (17), p.e15821-n/a
Main Authors:	Notarius, Catherine F., Badrov, Mark B., Tobushi, Tomoyuki, Keir, Daniel A., Keys, Evan, Floras, John S.
Format:	Article
Language:	eng
Subjects:	Aging arterial chemoreflex Baroreceptors Blood pressure cardiopulmonary baroreflex Chemoreception (internal) dynamic exercise Electrodes Exercise intensity Heart rate Hyperoxia Intervention Leg Load Microneurography Middle age muscle metaboreflex Musculoskeletal system Original Physical training Physiology Reflexes Sympathetic nerves Variance analysis
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Summary:	Aging augments resting muscle sympathetic nerve activity (MSNA) and sympatho‐inhibition during mild dynamic 1‐leg exercise. To elucidate which reflexes elicit exercise‐induced inhibition, we recruited 19 (9 men) healthy volunteers (mean age 56 ± 9 SD years), assessed their peak oxygen uptake (VO2peak), and, on another day, measured heart rate (HR), blood pressure (BP) and MSNA (microneurography) at rest and during 1‐leg cycling (2 min each at 0 load and 30%–40% VO2peak), 3 times: (1) seated +2 min of postexercise circulatory occlusion (PECO) (elicit muscle metaboreflex); (2) supine (stimulate cardiopulmonary baroreflexes);and (3) seated, breathing 32% oxygen (suppress peripheral chemoreceptor reflex). While seated, MSNA decreased similarly during mild and moderate exercise (p
ISSN:	2051-817X