Magnetic resonance markers of tissue damage related to connectivity disruption in multiple sclerosis

Patients with multiple sclerosis (MS) display reduced structural connectivity among brain regions, but the pathogenic mechanisms underlying network disruption are still unknown. We aimed to investigate the association between the loss of diffusion-based structural connectivity, measured with graph t...

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Bibliographic Details
Published in:	NeuroImage clinical 2018-01, Vol.20, p.161-168
Main Authors:	Solana, Elisabeth, Martinez-Heras, Eloy, Martinez-Lapiscina, Elena H., Sepulveda, Maria, Sola-Valls, Nuria, Bargalló, Nuria, Berenguer, Joan, Blanco, Yolanda, Andorra, Magi, Pulido-Valdeolivas, Irene, Zubizarreta, Irati, Saiz, Albert, Llufriu, Sara
Format:	Article
Language:	eng
Subjects:	Adult Brain - diagnostic imaging Brain - metabolism Cognition Female Frontal Lobe - diagnostic imaging Frontal Lobe - metabolism Frontoparietal network Humans Magnetic Resonance Spectroscopy - methods Male Middle Aged Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - metabolism Nerve Net - diagnostic imaging Nerve Net - metabolism Parietal Lobe - diagnostic imaging Parietal Lobe - metabolism Regular Spectroscopy magnetic resonance Structural connectivity
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Summary:	Patients with multiple sclerosis (MS) display reduced structural connectivity among brain regions, but the pathogenic mechanisms underlying network disruption are still unknown. We aimed to investigate the association between the loss of diffusion-based structural connectivity, measured with graph theory metrics, and magnetic resonance (MR) markers of microstructural damage. Moreover, we evaluated the cognitive consequences of connectivity changes. We analysed the frontoparietal network in 102 MS participants and 25 healthy volunteers (HV). MR measures included radial diffusivity (RD), as marker of demyelination, and ratios of myo-inositol, N-acetylaspartate and glutamate+glutamine with creatine in white (WM) and grey matter as markers of astrogliosis, neuroaxonal integrity and glutamatergic neurotoxicity. Patients showed decreased global and local efficiency, and increased assortativity (p
ISSN:	2213-1582 2213-1582