Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats

High-salt intake and high-fructose intake are risk factors for hypertension via oxidative stress and inflammation. T helper (Th)17 lymphocytes play an important role in the development of hypertension. Here, we tested the hypothesis that activation of pathogenic Th17 lymphocytes induces hypertension...

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Bibliographic Details

Published in:	Disease models & mechanisms 2020-05, Vol.13 (5)
Main Authors:	Lee, Eunjo, Kim, Namkyung, Kang, Jinjoo, Yoon, Sangwon, Lee, Hae-Ahm, Jung, Hanna, Kim, Sang-Hyun, Kim, Inkyeom
Format:	Article
Language:	eng
Subjects:	Animals Blood Pressure Body Weight Cardiovascular disease Cytokines Cytokines - blood Cytokines - metabolism dahl salt-resistant rat dahl salt-sensitive rat Diet Drinking water Forkhead Transcription Factors - metabolism Fructose Gene expression Glucose Glucose Intolerance - blood Glucose Intolerance - complications Glucose Intolerance - immunology Hypertension Hypertension - blood Hypertension - complications Hypertension - immunology Immediate-Early Proteins - metabolism Immune system Interleukin-23 - metabolism Kinases Lymphocyte Activation - immunology Lymphocytes Male Models, Biological Oxidative stress Phosphorylation Protein Serine-Threonine Kinases - metabolism Rats, Inbred Dahl Salt Signal Transduction Spleen Systole T-Lymphocytes, Regulatory - immunology Th17 Cells - immunology th17 lymphocytes Transcription factors treg lymphocytes
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