Propensity score regression analysis of oesophageal adenocarcinoma treatment with surgery alone or neoadjuvant chemotherapy

Background Propensity score (PS) regression analysis can be used to minimize differences between cohorts in order to perform comparisons The aim of this study was to use PS analysis to examine the outcomes of oesophageal adenocarcinoma (OAC) treatment with surgery alone or neoadjuvant chemotherapy (...

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Bibliographic Details
Published in:	BJS open 2020-08, Vol.4 (4), p.593-600
Main Authors:	Powell, A. G. M. T., Karran, A., Blake, P., Christian, A., Roberts, S. A., Lewis, W. G.
Format:	Article
Language:	eng
Subjects:	Cancer therapies Chemotherapy Medical research Morbidity Original Patients Regression analysis Surgery Upper GI Variables
Online Access:	Get full text
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Summary:	Background Propensity score (PS) regression analysis can be used to minimize differences between cohorts in order to perform comparisons The aim of this study was to use PS analysis to examine the outcomes of oesophageal adenocarcinoma (OAC) treatment with surgery alone or neoadjuvant chemotherapy (NAC) followed by surgery (NACS), to see whether the benefits seen in a randomized trial (MRC OE02) were reproducible in a UK cancer network clinical practice. Methods Consecutive patients undergoing potentially curative treatment for OAC in a regional cancer network were studied. Multiple regression models, including PS analysis, were developed to account for confounding factors. Primary outcome measures were disease‐free (DFS) and overall (OS) survival. Results A cohort of 440 patients was included in a regression analysis controlling for confounders (176 surgery alone, 264 NACS). NACS was associated with a higher positive margin status rate compared with surgery alone (42·4 versus 26·7 per cent respectively; P
ISSN:	2474-9842 2474-9842