Characterization of IgG Antibody Response against SARS-CoV-2 (COVID-19) in the Cypriot Population

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has hit its second year and continues to damage lives and livelihoods across the globe. There continues to be a global effort to present serological data on SARS-CoV-2 antibodies in different individuals. As such, this study a...

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Bibliographic Details
Published in:	Microorganisms (Basel) 2021-12, Vol.10 (1), p.85
Main Authors:	Krashias, George, Deeba, Elie, Constantinou, Astero, Hadjiagapiou, Maria, Koptides, Dana, Richter, Jan, Tryfonos, Christina, Bashiardes, Stavros, Lambrianides, Anastasia, Loizidou, Maria A, Hadjisavvas, Andreas, Panayiotidis, Mihalis I, Christodoulou, Christina
Format:	Article
Language:	eng
Subjects:	Antibody response Antigens Coronaviruses COVID-19 Herd immunity IgG antibody Immunoglobulin G Infections Monoclonal antibodies nucleocapsid (N) protein Pandemics Polymerase chain reaction Population SARS-CoV-2 Serology seroprevalence Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Software Spike 1 receptor binding protein Viral diseases Viruses
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Summary:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has hit its second year and continues to damage lives and livelihoods across the globe. There continues to be a global effort to present serological data on SARS-CoV-2 antibodies in different individuals. As such, this study aimed to characterize the seroprevalence of SARS-CoV-2 antibodies in the Cypriot population for the first time since the pandemic started. Our results show that a majority of people infected with SARS-CoV-2 developed IgG antibodies against the virus, whether anti-NP, anti-S1RBD, or both, at least 20 days after their infection. Additionally, the percentage of people with at least one antibody against SARS-CoV-2 in the group of volunteers deemed SARS-CoV-2 negative via RT-PCR or who remain untested/undetermined (14.43%) is comparable to other reported percentages worldwide, ranging anywhere from 0.2% to 24%. We postulate that these percentages reflect the underreporting of true infections in the population, and also show the steady increase of herd immunity. Additionally, we showed a significantly marked decrease in anti-NP IgG antibodies in contrast to relatively stable levels of anti-S1RBD IgG antibodies in previously infected individuals across time.
ISSN:	2076-2607 2076-2607