Post-infection cognitive impairments in a cohort of elderly patients with COVID-19

Abstract Background Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the current cognitive status and the longitudinal cognitive decline in elderly p...

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Published in:	Molecular neurodegeneration 2021-07, Vol.16 (1), p.1-48, Article 48
Main Authors:	Liu, Yu-Hui, Wang, Ye-Ran, Wang, Qing-Hua, Chen, Yang, Chen, Xian, Li, Ying, Cen, Yuan, Xu, Cheng, Hu, Tian, Liu, Xu-Dong, Yang, Ling-Li, Li, Si-Jing, Liu, Xue-Fei, Liu, Chun-Mei, Zhu, Jie, Li, Wei, Zhang, Li-Li, Liu, Juan, Wang, Yan-Jiang
Format:	Article
Language:	eng
Subjects:	Age Aged patients Body mass index Cardiovascular disease China Chronic obstructive pulmonary disease Cognitive ability Cognitive impairment Coronavirus Coronaviruses COVID-19 Delirium Dementia Dementia disorders Demographics Diabetes Education Health aspects Heart Hospital patients Hospitals Hypertension Infections Interviews Long-term effects Lung diseases, Obstructive Oxygen therapy Pandemics Patients Population decline Population studies Post infection Questionnaires Regression analysis Risk factors Severe acute respiratory syndrome coronavirus 2 Stroke Variables Ventilators
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Summary:	Abstract Background Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the current cognitive status and the longitudinal cognitive decline in elderly patients recovered from COVID-19. Methods This cross-sectional study recruited 1539 COVID-19 inpatients aged over 60 years who were discharged from three COVID-19-designated hospitals in Wuhan, China, from February 10 to April 10, 2020. In total, 466 uninfected spouses of COVID-19 patients were selected as controls. The current cognitive status was assessed using a Chinese version of the Telephone Interview of Cognitive Status-40 (TICS-40) and the longitudinal cognitive decline was assessed using an Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Cognitive assessments were performed 6 months after patient discharge. Results Compared with controls, COVID-19 patients had lower TICS-40 scores and higher IQCODE scores [TICS-40 median (IQR): 29 (25 to 32) vs. 30 (26 to 33), p
ISSN:	1750-1326 1750-1326