mRNA vaccine: a potential therapeutic strategy

mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In recent decades, we have witnessed the development of different kinds of mRNAs by sequence optimization to overcome the disadvantage of excessive m...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular cancer 2021-02, Vol.20 (1), p.33-33, Article 33
Main Authors:	Wang, Yang, Zhang, Ziqi, Luo, Jingwen, Han, Xuejiao, Wei, Yuquan, Wei, Xiawei
Format:	Article
Language:	eng
Subjects:	Adaptive immunity Animals Antibodies Antigens Cervical cancer Clinical trials Coronaviruses COVID-19 COVID-19 - immunology Delivery strategy Dendritic cells Deoxyribonucleic acid Diabetes DNA Emulsions Gene Transfer Techniques Health aspects Humans Immune system Immunity, Humoral Immunogenicity Immunotherapy Influenza Innate immunity Medical research Medicine, Experimental Messenger RNA Modification Molecular biology mRNA mRNA vaccine mRNA Vaccines Non-replicating mRNA Optimization Parasitic diseases Peptides Polymers Review RNA Stability Self-amplifying RNA Vaccines Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Viral diseases Virus diseases
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In recent decades, we have witnessed the development of different kinds of mRNAs by sequence optimization to overcome the disadvantage of excessive mRNA immunogenicity, instability and inefficiency. Based on the immunological study, mRNA vaccines are coupled with immunologic adjuvant and various delivery strategies. Except for sequence optimization, the assistance of mRNA-delivering strategies is another method to stabilize mRNAs and improve their efficacy. The understanding of increasing the antigen reactiveness gains insight into mRNA-induced innate immunity and adaptive immunity without antibody-dependent enhancement activity. Therefore, to address the problem, scientists further exploited carrier-based mRNA vaccines (lipid-based delivery, polymer-based delivery, peptide-based delivery, virus-like replicon particle and cationic nanoemulsion), naked mRNA vaccines and dendritic cells-based mRNA vaccines. The article will discuss the molecular biology of mRNA vaccines and underlying anti-virus and anti-tumor mechanisms, with an introduction of their immunological phenomena, delivery strategies, their importance on Corona Virus Disease 2019 (COVID-19) and related clinical trials against cancer and viral diseases. Finally, we will discuss the challenge of mRNA vaccines against bacterial and parasitic diseases.
ISSN:	1476-4598 1476-4598