Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive

Our aim was to analyze the relationship between abdominal obesity and general obesity, with subclinical atherosclerosis, arterial stiffness and wave reflection in healthy, diabetics and hypertensive subjects. A cross-sectional descriptive study was made of 305 individuals (diabetics 32.8%, hypertens...

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Bibliographic Details
Published in:	BMC cardiovascular disorders 2012-02, Vol.12 (1), p.3-3, Article 3
Main Authors:	Recio-Rodriguez, Jose I, Gomez-Marcos, Manuel A, Patino-Alonso, Maria C, Agudo-Conde, Cristina, Rodriguez-Sanchez, Emiliano, Garcia-Ortiz, Luis
Format:	Article
Language:	eng
Subjects:	Adult Aged Analysis Ankle Brachial Index Atherosclerosis Atherosclerosis - diagnosis Atherosclerosis - epidemiology Blood pressure Body Mass Index C-Reactive Protein - analysis Cardiovascular disease Cross-Sectional Studies Diabetes Mellitus - physiopathology Female Humans Hypertension - diagnosis Hypertension - physiopathology Male Measurement Middle Aged Obesity Obesity - complications Obesity - physiopathology Obesity, Abdominal - complications Obesity, Abdominal - physiopathology Studies Vascular Stiffness - physiology Veins & arteries Waist Circumference - physiology
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Summary:	Our aim was to analyze the relationship between abdominal obesity and general obesity, with subclinical atherosclerosis, arterial stiffness and wave reflection in healthy, diabetics and hypertensive subjects. A cross-sectional descriptive study was made of 305 individuals (diabetics 32.8%, hypertensive subjects 37.0% and healthy individuals 30.2%). Body mass index (BMI), waist circumference (WC), body fat percentage (BFP) and waist/height ratio (WHtR). Arterial stiffness was assessed according to pulse wave velocity (PWV), intima-media thickness of the common carotid artery (C-IMT), augmentation index (central and peripheral), ankle-brachial index (ABI), and central and peripheral pulse pressure. WC and WHtR showed a positive correlation to PWV and C-IMT in the studied groups. After adjusting for age, gender, high sensitivity c-reactive protein, serum glucose and the presence of diabetes, hypertension, smoking, dyslipidemia, antidiabetic drugs, lipid-lowering drugs, and atherosclerotic plaques, it was seen that for every 0.1 point increase in WHtR, and for every cm increase in WC, the PWV increased 0.041 and 0.029 m/sec, and C-IMT increased 0.001 mm and 0.001 mm, respectively. The measures of abdominal obesity (WHtR and WC) correlates better than BMI and BFP with arterial stiffness evaluated by PWV, and with subclinical atherosclerosis evaluated by C-IMT, independently of the presence of diabetes or hypertension. Clinical Trials.gov Identifier: NCT01325064.
ISSN:	1471-2261 1471-2261