Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana

Head and neck tumors (HNT) are tumors of the paranasal sinuses, the salivary glands and the upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties and has been implicated in a number of cancers. The aim of this study was to investigate the expression of RIN1...

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Bibliographic Details
Published in:	PloS one 2024-04, Vol.19 (4), p.e0301295-e0301295
Main Authors:	Osei Saahene, Roland, Barnes, Precious, Yeboah, F A, Agbo, Elvis, Asante, Du-Bois, Arhin, Samuel Kofi
Format:	Article
Language:	eng
Subjects:	Analysis Biology and Life Sciences Diagnosis Epithelial Cells Gene expression Genetic aspects Ghana Head and neck cancer Head and Neck Neoplasms - genetics Humans Intracellular Signaling Peptides and Proteins - genetics Medicine and Health Sciences Real-Time Polymerase Chain Reaction
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Summary:	Head and neck tumors (HNT) are tumors of the paranasal sinuses, the salivary glands and the upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties and has been implicated in a number of cancers. The aim of this study was to investigate the expression of RIN1 in head and neck tumors. RIN1 expression was assessed using quantitative real-time PCR (qRT-PCR) and immunohistochemical staining on archival head and neck tissue samples between 2014 and 2020. RIN1 expression was low in tissue samples as compared with the normal head and neck tissues. High and low RIN1 levels were compared with ages ≤40, >40 in the head and neck tumors of p-value 0.02. There was a significant difference with p-values of 0.001 when poor and well-moderate malignant tumors were compared. Our data suggests that RIN1may play an important role in head and neck tumor progression and that its expression may provide baseline data to facilitate identification of new molecular targeted therapeutics.
ISSN:	1932-6203 1932-6203