Metabolomic Analysis of Vitamin E Supplement Use in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

The effects of vitamin E supplementation on cancer and other chronic diseases are not clear. We compared the serum metabolomic profile of differing vitamin E dosages in order to re-examine the previously observed changes in a novel C lactone sulfate compound, androgenic steroids, and other metabolit...

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Bibliographic Details
Published in:	Nutrients 2023-06, Vol.15 (13), p.2836
Main Authors:	Lim, Jungeun, Hong, Hyokyoung G, Weinstein, Stephanie J, Playdon, Mary C, Cross, Amanda J, Stolzenberg-Solomon, Rachael, Freedman, Neal D, Huang, Jiaqi, Albanes, Demetrius
Format:	Article
Language:	eng
Subjects:	Alcohol Androgens Androstenediol Body mass index Cancer Cancer screening Cancer therapies Carbohydrates Care and treatment Colorectal Neoplasms Dietary Supplements Early Detection of Cancer Epidemiology Female Gas chromatography Gas Chromatography-Mass Spectrometry Humans Lipids Lung Lung cancer Male Males Mass spectrometry Mass spectroscopy Medical screening Metabolites Metabolomics Metabolomics - methods Oncology, Experimental Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - diagnosis Oxalic acid Prostate Prostate cancer Scientific imaging serum metabolomics Steroid hormones Steroids Sulfates Tocopherol Tocopherols Vitamin E vitamin E dosage vitamin E supplementation Vitamins
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Summary:	The effects of vitamin E supplementation on cancer and other chronic diseases are not clear. We compared the serum metabolomic profile of differing vitamin E dosages in order to re-examine the previously observed changes in a novel C lactone sulfate compound, androgenic steroids, and other metabolites. A total of 3409 women and men previously selected for metabolomics studies in the PLCO Cancer Screening Trial were included in this investigation. Serum metabolites were profiled using ultrahigh-performance liquid and gas chromatography/tandem mass spectrometry. Seventy known metabolites including C lactone sulfate and androgens were significantly associated with vitamin E supplementation. In the sex-stratified analysis, 10 cofactors and vitamins (e.g., alpha-CEHC sulfate and alpha-CEHC glucuronide), two carbohydrates (glyceric and oxalic acids), and one lipid (glycocholenate sulfate) were significantly associated with vitamin E dose in both males and females (FDR-adjusted -value < 0.01). However, the inverse association between C lactone sulfate and daily vitamin E supplementation was evident in females only, as were two androgenic steroids, 5-androstenediol and androsterone glucuronide. Our study provides evidence of distinct steroid hormone pathway responses based on vitamin E dosages. Further studies are needed to gain biological insights into vitamin E biochemical effects relevant to cancer and other chronic diseases.
ISSN:	2072-6643 2072-6643