Effects of Type 2 Diabetic Serum on Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells

Diabetic patients have an increased risk of osteoporosis-associated fractures. However, the results of most studies of the effects of diabetes on bone mass in patients with type 2 diabetes (T2DM) have been contradictory. To clarify these conflicting findings, we investigated the effects of diabetic...

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Bibliographic Details
Published in:Journal of diabetes research 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Cheng, Jinluo, Shen, Moyu, Xu, Min, Deng, Xiangqun
Format: Article
Language:English
Subjects:
Adipocytes
Adult
Age
Antibodies
Biotechnology industry
Bone marrow
Cell Proliferation - drug effects
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Female
Fractures
Humans
Hyperglycemia
Influence
Insulin
Laboratories
Male
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - drug effects
Middle Aged
Osteogenesis - drug effects
Osteoporosis
Osteoporotic Fractures - blood
Osteoporotic Fractures - etiology
Penicillin
Serum
Stem cells
Studies
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Summary:Diabetic patients have an increased risk of osteoporosis-associated fractures. However, the results of most studies of the effects of diabetes on bone mass in patients with type 2 diabetes (T2DM) have been contradictory. To clarify these conflicting findings, we investigated the effects of diabetic serum on the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). We used human sera from subjects with different levels of glycemic control to culture the MSCs and induce osteogenic differentiation. The rate of MSC proliferation differed when MSCs were cultured with sera from diabetic subjects with different levels of hyperglycemia. Hyperglycemic sera promoted MSC proliferation to some extent, but all the diabetic sera inhibited the differentiation of MSCs to osteoblasts. The effects of type 2 diabetic sera on the proliferation and osteogenic differentiation of MSCs are closely related to glycemic control. Our data demonstrate the importance of stratifying the study population according to glycemic control in clinical research into diabetic osteoporosis.
ISSN:2314-6745
2314-6753
DOI:10.1155/2018/5765478