The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome ac...

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Bibliographic Details

Published in:	Nature communications 2018-10, Vol.9 (1), p.4260-20, Article 4260
Main Authors:	Kasper, Lydia, König, Annika, Koenig, Paul-Albert, Gresnigt, Mark S, Westman, Johannes, Drummond, Rebecca A, Lionakis, Michail S, Groß, Olaf, Ruland, Jürgen, Naglik, Julian R, Hube, Bernhard
Format:	Article
Language:	eng
Subjects:	Actins - metabolism Animals Apoptosis Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Candida albicans Caspase 1 - metabolism Caspase-1 Cell activation Cell death Cell Death - drug effects Cytolysis Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Efflux Female Fungal Proteins - toxicity Fungi Glucose Humans Hyphae Immune clearance Immune system Inflammasomes Inflammasomes - metabolism Inflammation - pathology Innate immunity Interleukin-1beta - metabolism Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lysis Macrophages Macrophages - drug effects Macrophages - metabolism Mice, Inbred C57BL Mycotoxins - toxicity Necrosis NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Opportunist infection Pathogens Phagocytes Phagocytes - cytology Phagocytes - drug effects Phagocytes - metabolism Phagosomes - drug effects Phagosomes - metabolism Potassium Potassium - pharmacology
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