Association of B Cells with Idiopathic Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

Association of B Cells with Idiopathic Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

Recurrent pregnancy loss (RPL) affects 1-2% of women and is defined as having experienced two or more failed pregnancies. In almost 50% of cases, the causes are idiopathic (IRPL), but increasing evidence has suggested an immunological cause. B cells are known to provide crucial support for a success...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (23), p.15200
Main Authors: Ângelo-Dias, Miguel, Martins, Catarina, Dias, Sara Simões, Borrego, Luís Miguel, Lima, Jorge
Format: Article
Language:eng
Subjects:
Abortion
Abortion, Habitual
B cells
Bias
Endometrium
Female
Flow cytometry
Humans
idiopathic recurrent pregnancy loss
Immune system
Immunohistochemistry
Immunology
Lymphocytes B
MeSH
Meta-analysis
Pregnancy
Quality assessment
reproductive immunology
Review
Risk analysis
Risk Factors
Systematic review
Thyroid gland
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Summary:Recurrent pregnancy loss (RPL) affects 1-2% of women and is defined as having experienced two or more failed pregnancies. In almost 50% of cases, the causes are idiopathic (IRPL), but increasing evidence has suggested an immunological cause. B cells are known to provide crucial support for a successful pregnancy outcome. However, their involvement in the mechanisms underlying IRPL is still unclear. This systematic review and meta-analysis aimed to comprehensively summarise the existing evidence regarding the levels and profiles of B cells in IRPL. An extensive computerized search in PubMed/Medline, Embase, Scopus, and Web of Science databases was performed with no imposed limits. Two reviewers independently screened all retrieved studies, extracted all the data, and assessed the methodological quality. Disagreements were resolved by a third reviewer. From a total of 1125 retrieved studies, 19 studies were included in the systematic review, and 8 studies were quantitatively analysed. We highlight a potential association between women with IRPL and increased levels of endometrial B cells. In addition, the flow cytometry technique seems to be preferred over immunohistochemistry for identifying those differences, while further studies are necessary to clarify the role of B cells as an immunological risk factor for RPL.
ISSN:1422-0067
1661-6596
1422-0067