Rapid Emergence of Appetite and Hunger Resulting in Weight Gain and Improvement of Eating Disorder Symptomatology during and after Short-Term Off-Label Metreleptin Treatment of a Patient with Anorexia Nervosa

Abstract Off-label treatment of a 15-year-old female patient with anorexia nervosa (AN) with human recombinant leptin (metreleptin) for nine days was associated with self-reported increments of appetite and hunger resulting in rapid weight gain and substantial improvement of eating disorder cognitio...

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Bibliographic Details
Published in:Obesity facts 2023-01, Vol.16 (1), p.99-107
Main Authors: Gradl-Dietsch, Gertraud, Milos, Gabriella, Wabitsch, Martin, Bell, Rebecca, Tschöpe, Franziska, Antel, Jochen, Hebebrand, Johannes
Format: Article
Language:English
Subjects:
Adolescent
Anorexia
Anorexia Nervosa - complications
Anorexia Nervosa - drug therapy
Appetite
Case Report
Case reports
Consent
Eating disorders
Enteral nutrition
Feeding and Eating Disorders
Female
Females
Food
Humans
Hunger
Leptin - therapeutic use
Lymphoma
Meals
Nervous system
Obesity
Off-Label Use
Patients
Weight control
Weight Gain
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Summary:Abstract Off-label treatment of a 15-year-old female patient with anorexia nervosa (AN) with human recombinant leptin (metreleptin) for nine days was associated with self-reported increments of appetite and hunger resulting in rapid weight gain and substantial improvement of eating disorder cognitions and of depression. The results further substantiate the effects of metreleptin on both AN and depression. We contrast these results with the widespread view that leptin is an anorexigenic hormone. Randomized controlled trials are warranted to confirm the described effects.
ISSN:1662-4025
1662-4033
DOI:10.1159/000527386