Biological variation in the serum and urine kidney injury markers of a healthy population measured within 24 hours

To explore the biological variation (BV) of kidney injury markers in serum and urine of healthy subjects within 24 hours to assist with interpretation of future studies using these biomarkers in the context of known BV. Serum and urine samples were collected every 4 hours (0, 4, 8, 12, 16 and 20 hou...

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Bibliographic Details
Published in:BMC nephrology 2022-05, Vol.23 (1), p.195-195, Article 195
Main Authors: Kong, Li-Rui, Wei, Fei, He, Da-Hai, Zhou, Chao-Qiong, Li, Hong-Chuan, Wu, Feng, Luo, Yu, Luo, Jian-Wei, Xie, Qian-Rong, Peng, Hai, Zhang, Yan
Format: Article
Language:English
Subjects:
Acute Kidney Injury
Analysis
Biological markers
Biological variation
Biomarkers
Blood lipoproteins
Care and treatment
Casualties
Chinese medicine
Creatinine
Cystatin C
Diagnosis
Female
Females
Gelatinase
Gelatinases
Hospital patients
Humans
Individual index
Kidney
Kidney diseases
Kidney injury markers
Kidneys
Leukocytes (neutrophilic)
Lipocalin-2 - urine
Lipoproteins
Male
Males
Nephrology
Population
Proteolipids
Quality control
Reference change value
Risk factors
Urine
Variation
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Summary:To explore the biological variation (BV) of kidney injury markers in serum and urine of healthy subjects within 24 hours to assist with interpretation of future studies using these biomarkers in the context of known BV. Serum and urine samples were collected every 4 hours (0, 4, 8, 12, 16 and 20 hours) from 31 healthy subjects within 24 hours and serum creatinine (s-Crea), serum β2-microglobin (s-β2MG), serum cystatin C (s-CYSC), serum neutrophil gelatinase-associated lipoprotein (s-NGAL), urine creatinine (u-Crea), urine β2-microglobin (u-β2MG), urine cystatin C (u-CYSC), urine neutrophil gelatinase-associated lipoprotein (u-NGAL) were measured. Outlier and variance homogeneity analyses were performed, followed by CV-ANOVA analysis on trend-corrected data (if relevant), and analytical (CV ), within-subject (CV ), and between-subject (CV ) biological variation were calculated. The concentration of kidney injury markers in male was higher than that in female, except for u-CYSC and u-NGAL. There were no significant difference in serum and urine kidney injury markers concentration at different time points. Serum CV was lower than urine CV , serum CV was higher than CV , and urine CV was lower than CV . The individual index (II) of serum kidney injury markers was less than 0.6, while the II of urinary kidney injury markers was more than 1.0. This study provides new short-term BV data for kidney injury markers in healthy subjects within 24 hours, which are of great significance in explaining other AKI / CKD studies.
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-022-02819-2