Residual risk of mother-to-child transmission of HBV despite timely Hepatitis B vaccination: a major challenge to eliminate hepatitis B infection in Cambodia

In countries with intermediate or high hepatitis B virus (HBV) endemicity, mother-to-child transmission (MTCT) represents the main route of chronic HBV infection. There is a paucity of information on HBV MTCT in Cambodia. This study aimed to investigate the prevalence of HBV infection among pregnant...

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Published in:	BMC infectious diseases 2023-04, Vol.23 (1), p.261-261, Article 261
Main Authors:	E, Bunthen, Ko, Ko, Kim, Rattana, Nagashima, Shintaro, Ouoba, Serge, Hussain, Md Razeen Ashraf, Sato, Tomoki, Chuon, Channarena, Abe, Kanon, Sugiyama, Aya, Takahashi, Kazuaki, Akita, Tomoyuki, Tung, Rathavy, Ork, Vichit, Hossain, Md Shafiqul, Saphonn, Vonthanak, Tanaka, Junko
Format:	Article
Language:	eng
Subjects:	Age Analysis Antibodies Antigens Antiviral agents Babies Cambodia - epidemiology Chemiluminescence Chronic infection COVID-19 Disease transmission DNA sequencing Dosage and administration Enzyme immunoassay Epidemiology Female Genomes Guidelines HBeAg Health risks Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - prevention & control Hepatitis B e antigen Hepatitis B e Antigens Hepatitis B surface antigen Hepatitis B Surface Antigens Hepatitis B vaccine Hepatitis B Vaccines Hepatitis B Virus Hepatitis B virus - genetics Homology Humans Immunization Immunoassay Infant Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Longitudinal Studies Maternal & child health Maternal-fetal exchange Medical records Mother-to-child transmission Mothers Nucleotide sequencing Polymerase chain reaction Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - prevention & control Pregnant women Prevalence Prevention Prophylaxis Public health Risk factors Sample size Vaccination Vaccines Viruses
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Summary:	In countries with intermediate or high hepatitis B virus (HBV) endemicity, mother-to-child transmission (MTCT) represents the main route of chronic HBV infection. There is a paucity of information on HBV MTCT in Cambodia. This study aimed to investigate the prevalence of HBV infection among pregnant women and its MTCT rate in Siem Reap, Cambodia. This longitudinal study included two parts, study-1 to screen HBsAg among pregnant women and study-2 to follow up babies of all HBsAg-positive and one-fourth of HBsAg-negative mothers at their delivery and six-month post-partum. Serum or dried blood spot (DBS) samples were collected to examine HBV sero-markers by chemiluminescent enzyme immunoassay (CLEIA), and molecular analyses were performed on HBsAg-positive samples. Structured questionnaires and medical records were used to examine the risk factors for HBV infection. MTCT rate was calculated by HBsAg positivity of 6-month-old babies born to HBsAg-positive mothers and ascertained by the homology of HBV genomes in mother-child pair at 6-month-old. A total of 1,565 pregnant women were screened, and HBsAg prevalence was 4.28% (67/1565). HBeAg positivity was 41.8% and was significantly associated with high viral load (p
ISSN:	1471-2334 1471-2334