The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex

The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex

The actin binding protein drebrin plays a key role in dendritic spine formation and synaptic plasticity. Decreased drebrin protein levels have been observed in temporal lobe epilepsy, suggesting the involvement of drebrin in the disease. Here we investigated the effect of drebrin knockout on physiol...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.8662-8662, Article 8662
Main Authors: Klemz, Alexander, Kreis, Patricia, Eickholt, Britta J, Gerevich, Zoltan
Format: Article
Language:eng
Subjects:
Actin
Animals
Blotting, Western
Cognitive ability
Convulsions & seizures
Cortex (entorhinal)
Cortex (temporal)
Dendritic plasticity
Dendritic spines
Entorhinal Cortex - physiology
Epilepsy
Excitability
Female
Hippocampus
Hippocampus - metabolism
Hippocampus - physiology
Male
Mice
Mice, Knockout
Nerve Net - physiology
Neuropeptides - physiology
Oscillations
Physiology
Proteins
Rats
Seizures
Seizures - metabolism
Seizures - physiopathology
Synaptic plasticity
Temporal lobe
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Summary:The actin binding protein drebrin plays a key role in dendritic spine formation and synaptic plasticity. Decreased drebrin protein levels have been observed in temporal lobe epilepsy, suggesting the involvement of drebrin in the disease. Here we investigated the effect of drebrin knockout on physiological and pathophysiological neuronal network activities in mice by inducing gamma oscillations, involved in higher cognitive functions, and by analyzing pathophysiological epileptiform activity. We found that loss of drebrin increased the emergence of spontaneous gamma oscillations suggesting an increase in neuronal excitability when drebrin is absent. Further analysis showed that although the kainate-induced hippocampal gamma oscillations were unchanged in drebrin deficient mice, seizure like events measured in the entorhinal cortex appeared earlier and more frequently. The results suggest that while drebrin is not essential for normal physiological network activity, it helps to protect against the formation of seizure like activities during pathological conditions. The data indicate that targeting drebrin function could potentially be a preventive or therapeutic strategy for epilepsy treatment.
ISSN:2045-2322
2045-2322