Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer

Clinical studies indicate chemotherapy agents used in childhood cancer treatment regimens may impact future fertility. However, effects of individual agents on prepubertal human testis, necessary to identify later risk, have not been determined. The study aimed to investigate the impact of cisplatin...

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Bibliographic Details

Published in:	BMC medicine 2020-12, Vol.18 (1), p.374-16, Article 374
Main Authors:	Tharmalingam, Melissa D, Matilionyte, Gabriele, Wallace, William H B, Stukenborg, Jan-Bernd, Jahnukainen, Kirsi, Oliver, Elizabeth, Goriely, Anne, Lane, Sheila, Guo, Jingtao, Cairns, Bradley, Jorgensen, Anne, Allen, Caroline M, Lopes, Federica, Anderson, Richard A, Spears, Norah, Mitchell, Rod T
Format:	Article
Language:	eng
Subjects:	Adolescent development Animals Apoptosis Biopsy Cancer Cancer in children Cancer therapies Carboplatin Carboplatin - adverse effects Carboplatin - pharmacology Cell culture Cell number Cell proliferation Chemotherapy Child Children Cisplatin Cisplatin - adverse effects Cisplatin - pharmacology Complications and side effects Dosage and administration Drug therapy Ethics Experiments Exposure Fertility Fertility Preservation - methods Germ cell Germ cells Health aspects Human Humans Infertility Male Medicin och hälsovetenskap Mice Neoplasms - complications Neoplasms - drug therapy Pediatrics Physiological aspects Platinum Populations Prepubertal Reduction Risk factors Spermatogonia Stem cells Testes Testis Testis - drug effects Tissues Toxicity Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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