Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction

Circular RNAs (circRNAs) are recently identified as a class of non-coding RNAs that participate in the incidence of acute myocardial infarction (AMI). However, circRNAs expression pattern in obstructive sleep apnea (OSA) with AMI remains unknown. The aim was to investigate circRNAs expression altera...

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Published in:BMC medical genomics 2023-03, Vol.16 (1), p.50-50, Article 50
Main Authors: Huang, Jie-Feng, Lian, Ning-Fang, Lin, Guo-Fu, Xie, Han-Sheng, Wang, Bi-Ying, Chen, Gong-Ping, Lin, Qi-Chang
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Airway management
Apnea
Biomarkers
Circular RNAs
Complications and side effects
Diagnosis
Diagnostic biomarker
Exosomes
Genes
Health aspects
Heart attack
Heart attacks
Humans
Medical imaging
MicroRNAs
Myocardial infarction
Next-generation sequencing
Obstructive sleep apnea
Risk factors
RNA - metabolism
RNA sequencing
RNA, Circular - genetics
RNA, Circular - metabolism
Sleep apnea
Sleep apnea syndromes
Sleep disorders
Software
Therapeutic targets
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Summary:Circular RNAs (circRNAs) are recently identified as a class of non-coding RNAs that participate in the incidence of acute myocardial infarction (AMI). However, circRNAs expression pattern in obstructive sleep apnea (OSA) with AMI remains unknown. The aim was to investigate circRNAs expression alteration in serum exosomes derived from OSA patients with AMI. The serum exosomal circRNAs profile of three healthy subjects, three OSA without AMI and three OSA with AMI were analyzed using high-throughput sequencing. Bioinformatic analyses were carried out to assess potential core circRNAs and functional analyses were conducted to study biological functions. Compared to healthy subjects, there were 5225 upregulated and 5798 downregulated circRNAs in exosomes from OSA with AMI patients. And our study also identified 5210 upregulated and 5813 downregulated circRNAs in OSA with AMI patients compared to OSA without AMI. The differential expression of 2 circRNAs (hsa_circRNA_101147, hsa_circRNA_101561) between healthy subjects and OSA without AMI, and 4 circRNAs (hsa_circRNA_101328, hsa_circRNA_104172, hsa_circRNA_104640, hsa_circRNA_104642) between healthy subjects and OSA with AMI were confirmed by qRT-PCR. In addition, we demonstrated that miR-29a-3p targeted hsa_circRNA_104642 directly. This study demonstrated that there were a number of dysregulated circRNAs in exosomes from OSA with AMI patients, which might be effectively served as a promising diagnostic biomarker and therapeutic targets.
ISSN:1755-8794
1755-8794
DOI:10.1186/s12920-023-01464-4