Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies

Transforaminal lumber interbody fusion (TLIF) is the last resort to address the lumber degenerative disorders such as spondylolisthesis, causing lower back pain. The current surgical intervention for these abnormalities includes open TLIF. However, in recent years, minimally invasive TLIF (MIS-TLIF)...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of molecular sciences 2021-03, Vol.22 (7), p.3638
Main Authors:	Lo, Wen-Cheng, Tsai, Lung-Wen, Yang, Yi-Shan, Chan, Ryan Wing Yuk
Format:	Article
Language:	eng
Subjects:	Abnormalities Back pain Back surgery Biocompatible Materials - pharmacology Biomaterials Biomedical materials bone graft Bone Transplantation - trends Cells (biology) Ceramics Clinical outcomes Combinatorial analysis Composite materials Endoscopy Humans Infections Intervertebral Disc Degeneration - surgery Learning curves Low back pain Lumbar Vertebrae - surgery Lumbosacral Region - surgery Minimally Invasive Surgical Procedures - methods Minimally Invasive Surgical Procedures - trends MIS-TLIF Patients platelet-derived biomaterials Progenitor cells Radiation Regenerative Medicine - methods Review Skin & tissue grafts Spinal Fusion - methods Spinal Fusion - trends Spondylolisthesis Spondylolisthesis - surgery Stem cells Surgeons Surgery Three dimensional printing Tissue engineering Treatment Outcome
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Transforaminal lumber interbody fusion (TLIF) is the last resort to address the lumber degenerative disorders such as spondylolisthesis, causing lower back pain. The current surgical intervention for these abnormalities includes open TLIF. However, in recent years, minimally invasive TLIF (MIS-TLIF) has gained a high momentum, as it could minimize the risk of infection, blood loss, and post-operative complications pertaining to fusion surgery. Further advancement in visualizing and guiding techniques along with grafting cage and materials are continuously improving the safety and efficacy of MIS-TLIF. These assistive techniques are also playing a crucial role to increase and improve the learning curve of surgeons. However, achieving an appropriate output through TLIF still remains a challenge, which might be synergized through 3D-printing and tissue engineering-based regenerative therapy. Owing to their differentiation potential, biomaterials such as stem/progenitor cells may contribute to restructuring lost or damaged tissues during MIS-TLIF, and this therapeutic efficacy could be further supplemented by platelet-derived biomaterials, leading to improved clinical outcomes. Thus, based on the above-mentioned strategies, we have comprehensively summarized recent developments in MIS-TLIF and its possible combinatorial regenerative therapies for rapid and long-term relief.
ISSN:	1422-0067 1661-6596 1422-0067