Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy

Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLI...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of chronic obstructive pulmonary disease 2017-01, Vol.12, p.451-460
Main Authors:	Martin, Mickaël, Almeras, Natalie, Després, Jean-Pierre, Coxson, Harvey O, Washko, George R, Vivodtzev, Isabelle, Wouters, Emiel Fm, Rutten, Erica, Williams, Michelle C, Murchison, John T, MacNee, William, Sin, Don D, Maltais, François
Format:	Article
Language:	eng
Subjects:	Abdomen abdominal adiposity Abdominal Muscles - diagnostic imaging Abdominal Muscles - physiopathology Adiposity Aged Analysis Body composition Body fat Body mass index Calcification Cardiovascular disease Case-Control Studies Chronic obstructive lung disease Chronic obstructive pulmonary disease Clinical outcomes Comorbidity Complications and side effects Coronary vessels Diabetes Disease Progression Exercise Tolerance Female Forced Expiratory Volume Health status indicators Humans Hypertension Intra-Abdominal Fat - diagnostic imaging Intra-Abdominal Fat - physiopathology Life Sciences Longitudinal Studies Lung - physiopathology Lung diseases, Obstructive Male Medical imaging metabolic syndrome Metabolism Middle Aged Mortality muscle Obesity Original Research Patients Prognosis Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - physiopathology Quality of Life Risk factors Thorax Tomography Tomography, X-Ray Computed Walk Test
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) substudy tested the hypothesis that COPD is associated with increased ectopic fat accumulation and that this would be associated with COPD-related outcomes and comorbidities. Computed tomography (CT) images of the thorax obtained in ECLIPSE were used to quantify ectopic fat accumulation at L2-L3 (eg, cross-sectional area [CSA] of visceral adipose tissue [VAT] and muscle tissue [MT] attenuation, a reflection of muscle fat infiltration) and CSA of MT. A dose-response relationship between CSA of VAT, MT attenuation and CSA of MT and COPD-related outcomes (6-minute walking distance [6MWD], exacerbation rate, quality of life, and forced expiratory volume in 1 second [FEV ] decline) was addressed with the Cochran-Armitage trend test. Regression models were used to investigate possible relationships between CT body composition indices and comorbidities. From the entire ECLIPSE cohort, we identified 585 subjects with valid CT images at L2-L3 to assess body composition. CSA of VAT was increased (
ISSN:	1178-2005 1176-9106 1178-2005