Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold

Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold

Abstract Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated exte...

Full description

Saved in:
Bibliographic Details
Published in:Communications biology 2023-10, Vol.6 (1), p.1017-1017, Article 1017
Main Authors: Yacoub, Magdi H., Tseng, Yuan-Tsan, Kluin, Jolanda, Vis, Annemijn, Stock, Ulrich, Smail, Hassiba, Sarathchandra, Padmini, Aikawa, Elena, El-Nashar, Hussam, Chester, Adrian H., Shehata, Nairouz, Nagy, Mohamed, El-sawy, Amr, Li, Wei, Burriesci, Gaetano, Salmonsmith, Jacob, Romeih, Soha, Latif, Najma
Format: Article
Language:eng
Subjects:
Biology
Connective tissues
Extracellular matrix
Heart diseases
Morbidity
Morphogenesis
Nerves
Quality of life
Regulatory sequences
Rheumatic heart disease
Tissue engineering
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.
ISSN:2399-3642
2399-3642