Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

This work aimed to evaluate the effects of dietary supplementation with β-glucans extracted from yeast ( ) and microalga ( ) on gene expression, oxidative stress biomarkers and plasma immune parameters in gilthead seabream ( ) juveniles. A practical commercial diet was used as the control (CTRL), an...

Full description

Saved in:

Bibliographic Details
Published in:	Marine drugs 2021-11, Vol.19 (12), p.653
Main Authors:	Reis, Bruno, Gonçalves, Ana Teresa, Santos, Paulo, Sardinha, Manuel, Conceição, Luís E C, Serradeiro, Renata, Pérez-Sánchez, Jaume, Calduch-Giner, Josep, Schmid-Staiger, Ulrike, Frick, Konstantin, Dias, Jorge, Costas, Benjamín
Format:	Article
Language:	eng
Subjects:	Algae Animal Feed Animals Antibiotics Antioxidants Antioxidants - metabolism Aquaculture Aquatic microorganisms Aquatic Organisms Bacteria beta-Glucans - administration & dosage Biomarkers Body weight Diet Dietary supplements Discrimination Epidemics Fish Gene expression Glucan Glucans Hematology Immune status Immune system immune tolerance Immunity, Innate Immunological tolerance Immunomodulation Intestine Intestines Juveniles Lipid peroxidation Lipids Liver - metabolism Marine fish Microalgae Multivariate analysis Nutrition research Oxidants Oxidative stress Oxidizing agents Pathogens Phaeodactylum tricornutum Physiology Prebiotics pulse feeding Saccharomyces cerevisiae Satiety Sea Bream Signal transduction Sparus aurata Supplementation Tolerance Yeast Yeast, Dried - administration & dosage Yeasts β-glucans
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This work aimed to evaluate the effects of dietary supplementation with β-glucans extracted from yeast ( ) and microalga ( ) on gene expression, oxidative stress biomarkers and plasma immune parameters in gilthead seabream ( ) juveniles. A practical commercial diet was used as the control (CTRL), and three others based on CTRL were further supplemented with different β-glucan extracts. One was derived from (diet MG) and two different extracts of 21% and 37% -derived β-glucans (defined as Phaeo21 and Phaeo37), to give a final 0.06% β-glucan dietary concentration. Quadruplicate groups of 95 gilthead seabream (initial body weight: 4.1 ± 0.1 g) were fed to satiation three times a day for 8 weeks in a pulse-feeding regimen, with experimental diets intercalated with the CTRL dietary treatment every 2 weeks. After 8 weeks of feeding, all groups showed equal growth performance and no changes were found in plasma innate immune status. Nonetheless, fish groups fed β-glucans supplemented diets showed an improved anti-oxidant status compared to those fed CTRL at both sampling points (i.e., 2 and 8 weeks). The intestinal gene expression analysis highlighted the immunomodulatory role of Phaeo37 diet after 8 weeks, inducing an immune tolerance effect in gilthead seabream intestine, and a general down-regulation of immune-related gene expression. In conclusion, the results suggest that the dietary pulse administration of a 37% enriched-β-glucans extract might be used as a counter-measure in a context of gut inflammation, due to its immune-tolerant and anti-oxidative effects.
ISSN:	1660-3397 1660-3397