Risk factors for incident delirium among urological patients: a systematic review and meta-analysis with GRADE summary of findings

Risk factors for incident delirium among urological patients: a systematic review and meta-analysis with GRADE summary of findings

Abstract Background Post-operative delirium is an important, yet under-researched complication of surgery. Patients undergoing urological surgery may be at especially high risk of POD, as they are often older, and interventions can be associated with conditions that trigger delirium. The main aim of...

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Bibliographic Details
Published in:BMC urology 2020-10, Vol.20 (1), p.1-169, Article 169
Main Authors: Sanyaolu, L, Scholz, A. F. M, Mayo, I, Coode-Bate, J, Oldroyd, C, Carter, B, Quinn, T, Hewitt, J
Format: Article
Language:eng
Subjects:
Age
Bias
Delirium
Elderly
Epidemiology
Heart surgery
Medical research
Meta-analysis
Mortality
Older people
Patients
Population studies
Risk factors
Statistical analysis
Surgery
Systematic review
Urology
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Summary:Abstract Background Post-operative delirium is an important, yet under-researched complication of surgery. Patients undergoing urological surgery may be at especially high risk of POD, as they are often older, and interventions can be associated with conditions that trigger delirium. The main aim of this systematic review was to evaluate the available evidence for risk factors in this patient group. Methods Five databases were searched (MEDLINE, Web of Science, EMBASE, CINAHL and PsychInfo) between January 1987 and June 2019. The Newcastle–Ottawa Scale was used to assess for risk of bias. Pooled odds ratio or mean difference (MD) for individual risk factors were estimated using the Mantel–Haenzel and inverse variance methods. Results Seven articles met the inclusion criteria, giving a total population of 1937. The incidence of POD ranged from 5 to 29%. Three studies were deemed low risk of bias and four at a high risk of bias. Nine risk factors were suitable for meta-analysis, with age (MD 4.314 95% CI 1.597, 7.032 p = 0.002) and the clock drawing test (MD − 2.443 95% CI − 3.029, − 1.857 p 
ISSN:1471-2490
1471-2490