Heterogeneity of White Matter Hyperintensities in Cognitively Impaired Patients With Cerebral Small Vessel Disease

Similar white matter hyperintensities (WMH) might have different impact on the cognitive outcomes in patients with cerebral small vessel disease (CSVD). This study is to assess the possible factors related to the heterogeneity of WMH in cognitively impaired patients with CVSD. We analyzed data from...

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Bibliographic Details
Published in:	Frontiers in immunology 2021-12, Vol.12, p.803504-803504
Main Authors:	Wang, Tingting, Jin, Aoming, Fu, Ying, Zhang, Zaiqiang, Li, Shaowu, Wang, David, Wang, Yilong
Format:	Article
Language:	eng
Subjects:	Aged cerebral small vessel disease Cerebral Small Vessel Diseases - diagnostic imaging Cerebral Small Vessel Diseases - pathology Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - pathology cognitive impairment Cross-Sectional Studies Female heterogeneity Humans Immunology Magnetic Resonance Imaging - methods Male Middle Aged Neuroimaging - methods ultrasmall superparamagnetic iron oxide (USPIO) White Matter - diagnostic imaging White Matter - pathology white matter hyperintensities
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Summary:	Similar white matter hyperintensities (WMH) might have different impact on the cognitive outcomes in patients with cerebral small vessel disease (CSVD). This study is to assess the possible factors related to the heterogeneity of WMH in cognitively impaired patients with CVSD. We analyzed data from a cohort of patients with CVSD who were recruited consecutively from the Beijing Tiantan Hospital from 2015 to 2020. WMH, lacunes, enlarged perivascular space (ePVS), microbleeds and lacunar infarcts were rated on brain MRI. A score of
ISSN:	1664-3224 1664-3224