Water-Soluble Chalcogenide W6-Clusters: On the Way to Biomedical Applications

Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detail...

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Bibliographic Details
Published in:	International journal of molecular sciences 2022-08, Vol.23 (15), p.8734
Main Authors:	Gassan, Alena D., Ivanov, Anton A., Pozmogova, Tatiana N., Eltsov, Ilia V., Kuratieva, Natalia V., Mironov, Yuri V., Shestopalov, Michael A.
Format:	Article
Language:	eng
Subjects:	Angiography Aqueous solutions Biocompatibility Biomedical materials Cell viability Clusters Computed tomography Contrast agents crystal structure Cytotoxicity Electrochemical analysis Ligands Molybdenum NMR Nuclear magnetic resonance octahedral chalcogenide tungsten clusters Phosphine Phosphines Phosphorus Structural analysis Tungsten Water chemistry water solubility X-rays
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Summary:	Despite the great potential of octahedral tungsten cluster complexes in fields of biomedical applications such as X-ray computed tomography or angiography, there is only one example of a water-soluble W6Q8-cluster that has been reported in the literature. Herein we present the synthesis and a detailed characterization including X-ray structural analysis, NMR, IR, UV–Vis spectroscopies, HR-MS spectrometry, and the electrochemical behavior of two new cluster complexes of the general formula W6Q8L6 with phosphine ligands containing a hydrophilic carboxylic group, which makes the complexes soluble in an aqueous medium. The hydrolytic stability of the clusters’ aqueous solutions allows us to investigate for the first time the influence of W6-clusters on cell viability. The results obtained clearly demonstrate their very low cytotoxicity, comparable to the least-toxic clusters presented in the literature.
ISSN:	1422-0067 1661-6596 1422-0067