Human Milk Oligosaccharides: 2'-Fucosyllactose (2'-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula

The authors reviewed the published evidence on the presence of oligosaccharides in human milk (HMO) and their benefits in in vitro and in vivo studies. The still limited data of trials evaluating the effect of mainly 2'-fucosyllactose (2'-FL) on the addition of some of HMOs to infant formu...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrients 2018-08, Vol.10 (9), p.1161
Main Authors:	Vandenplas, Yvan, Berger, Bernard, Carnielli, Virgilio Paolo, Ksiazyk, Janusz, Lagström, Hanna, Sanchez Luna, Manuel, Migacheva, Nathalia, Mosselmans, Jean-Marc, Picaud, Jean-Charles, Possner, Mike, Singhal, Atul, Wabitsch, Martin
Format:	Article
Language:	eng
Subjects:	2′-fucosyllactose Animals Babies Baby foods bifidobacteria Blood groups Brain - growth & development Brain - metabolism breast feeding Breast milk Child Development Clinical trials Cow's milk Diabetes Ear diseases Enzymes Epithelial cells Food and Nutrition formula feeding Gastrointestinal Microbiome Genes Genetic factors Hospitals human milk oligosaccharide Humans Immune response Immunity, Mucosal In vivo methods and tests Infant Formula - chemistry Infant Nutritional Physiological Phenomena Infant, Newborn Infants Infectious diseases Intestinal microflora Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Lactation Lacto-N-neotetraose Life Sciences Marriage Microbiota Milk Milk, Human - immunology Milk, Human - metabolism Nutrition Nutritional Status Nutritive Value Oligosaccharides Oligosaccharides - immunology Oligosaccharides - metabolism Pediatrics Review Reviews Trisaccharides - immunology Trisaccharides - metabolism Womens health
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The authors reviewed the published evidence on the presence of oligosaccharides in human milk (HMO) and their benefits in in vitro and in vivo studies. The still limited data of trials evaluating the effect of mainly 2'-fucosyllactose (2'-FL) on the addition of some of HMOs to infant formula were also reviewed. PubMed was searched from January 1990 to April 2018. The amount of HMOs in mother's milk is a dynamic process as it changes over time. Many factors, such as duration of lactation, environmental, and genetic factors, influence the amount of HMOs. HMOs may support immune function development and provide protection against infectious diseases directly through the interaction of the gut epithelial cells or indirectly through the modulation of the gut microbiota, including the stimulation of the bifidobacteria. The limited clinical data suggest that the addition of HMOs to infant formula seems to be safe and well tolerated, inducing a normal growth and suggesting a trend towards health benefits. HMOs are one of the major differences between cow's milk and human milk, and available evidence indicates that these components do have a health promoting benefit. The addition of one or two of these components to infant formula is safe, and brings infant formula closer to human milk. More prospective, randomized trials in infants are need to evaluate the clinical benefit of supplementing infant formula with HMOs.
ISSN:	2072-6643 2072-6643