Phenylglyoxal-based visualization of citrullinated proteins on Western blots

Citrullination is the conversion of peptidylarginine to peptidylcitrulline, which is catalyzed by peptidylarginine deiminases. This conversion is involved in different physiological processes and is associated with several diseases, including cancer and rheumatoid arthritis. A common method to detec...

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Bibliographic Details

Published in:	Molecules (Basel, Switzerland) Switzerland), 2015-04, Vol.20 (4), p.6592-6600
Main Authors:	Hensen, Sanne M M, Boelens, Wilbert C, Bonger, Kimberly M, van Cruchten, Remco T P, van Delft, Floris L, Pruijn, Ger J M
Format:	Article
Language:	eng
Subjects:	Animals anti-modified citrulline antibodies Antibodies azide-alkyne cycloaddition Blotting, Western - methods Catalysis citrulline Citrulline - chemistry Humans Hydrolases - metabolism Indicators and Reagents - chemistry Membranes peptidylarginine deiminases phenylglyoxal Phenylglyoxal - chemistry Polypeptides Protein-Arginine Deiminases Proteins Proteins - chemistry Proteins - metabolism Rheumatoid arthritis Staining and Labeling Visualization
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